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Biography – Dra. Claudia Quezada Monrás

Dra. Claudia Quezada Monrás
Investigador Principal
Universidad Austral de Chile

Dr. Claudia Quezada Monrás is a Full Professor and Senior Researcher at the Tumor Biology Laboratory of the Institute of Biochemistry and Microbiology of the Faculty of Sciences of the Austral University of Chile. She is a graduate of Biochemistry from the Austral University of Chile and a PhD in Molecular Biosciences from the Andrés Bello University. She has carried out international research stays in cancer research centers such as the prestigious Vall’De Hebron Oncology Hospital and Research Center. Her interest in her research has focused on the study of various mechanisms of tumor resistance, from basic research to clinical trials in collaboration with national and international health and research centers. She has participated in various scientific societies receiving various awards for her research and was Director of the Southern Zone of the Society of Biochemistry and Molecular Biology of Chile.

In 2013 he obtained the National Prize for University Scientific Research “Cure and Prevention of Cancer” and in 2022 he received the Los Ríos Region Medal for his contribution to regional development in Science and innovation, and has become a leader and co-investigator of various R + D + i projects, including FONDECYT, FONDEQUIP, FIDECNO, FIC, ANILLOS DE INVESTIGACION, FONDEF. Currently, he is investigating the role of adenosine and its low-affinity receptors as endogenous modulators of resistance mechanisms to treatment in brain tumors such as glioblastoma and the search for immunological biomarkers and drug resistance in gallbladder cancer. At the management level, she has been a Member of the Academic Council and Superior University Council and is currently Director of Research at the Universidad Austral de Chile.

Publications

  1. José Ignacio Erices, Carolina Bizama, Ignacio Niechi, Daniel Uribe, Arnaldo Rosales, Karen Fabres, Giovanna Navarro-Martínez, Ángelo Torres, Rody San Martín, Juan Carlos Roa, and Claudia Quezada-Monrás (2023). Glioblastoma Microenvironment and Invasiveness: New Insights and Therapeutic Targets. Int J Mol Sci.; 24(8): 7047.
  2. Ignacio Niechi, José I. Erices, Diego Carrillo-Beltrán, Atenea Uribe-Ojeda, Ángelo Torres, José Dellis Rocha, Daniel Uribe, María A. Toro, Karla Villalobos-Nova, Belén Gaete-Ramírez, Gabriel Mingo, Gareth I. Owen, Manuel Varas-Godoy, Lilian Jara, Francisco Aguayo, Verónica A. Burzio, Claudia Quezada-Monrás, and Julio C. Tapia. (2023) Cancer Stem Cell and Aggressiveness Traits Are Promoted by Stable Endothelin-Converting Enzyme-1c in Glioblastoma Cells. Cells.12(3): 506.
  3. Andrés Tittarelli, Omar Barría, Evy Sanders, Anna Bergqvist, Daniel Uribe Brange, Mabel Vidal, María Alejandra Gleisner, Jorge Ramón Vergara, Ignacio Niechi, Iván Flores, Cristián Pereda,Cristian Carrasco, Claudia Quezada-Monrás and Flavio Salazar-Onfray. (2023) Co-Expression of Immunohistochemical Markers MRP2, CXCR4, and PD-L1 in Gallbladder Tumors Is Associated with Prolonged Patient Survival. Cancers, 15, 3440.
  4. Pérez-Baños A, Gleisner MA, Flores I, Pereda C , Navarrete M, Araya JP, Navarro G, Quezada- Monrás C , Tittarelli A, Salazar-Onfray F. (2023) Whole tumour cell-based vaccines: tuning theinstruments to orchestrate an optimal antitumour immune response. (2023). British Journal of Cancer, 24 Jun 2023.
  5. Ángelo Torres-Arévalo, Yéssica Nahuelpán, Katherin Muñoz, Claudia Jara, Claudio Cappelli,Agnieszka Taracha-Wis ́niewska, Claudia Quezada-Monrás and Rody San Martín. (2023) A2BAR Antagonism Decreases the Glomerular Expression and Secretion of Chemoattractants for Monocytes and the Pro-Fibrotic M2 Macrophages Polarization during Diabetic Nephropathy. Int. J. Mol. Sci., 24, 10829. Int. J. Mol. Sci., 24, 10829.
  6. Rocha, JD., Uribe B., D., Delgado, J., Niechi, I., Alarcón, S., Erices, JI., Melo, R., Fernández- Gajardo, R., Salazar-Onfray, F., San Martin, R., Quezada CA. (2022) A2B Adenosine Receptor Enhances Chemoresistance of Glioblastoma Stem-Like Cells under Hypoxia: New Insights into MRP3 Transporter Function. International Journal of Molecular Sciences. 23(16).
  7. Erices, JI., Niechi, I., Uribe-Ojeda, M., García-Romero, N., Carrión-Navarro, J., Monago-Sánchez, A., Ayuso-Sacido, A., San Martin, R., Quezada CA. (2022) The low affinity A2B adenosine receptor enhances migratory and invasive capacity in vitro and angiogenesis in vivo of glioblastoma stem-like cells. Frontiers in Oncology. 12(969993).
  8. Daniel Uribe, Ignacio Niech, Gorjana Rackov, José I. Erices, Rody San Martín and Claudia Quezada. (2022) Adapt to Persist: Glioblastoma Microenvironment and Epigenetic Regulation on Cell Plasticity. Biology, 11(2), 313.
  9. Carrasco C, Tittarelli A, Paillaleve N, Pozo MD, Rojas-Sepúlveda D, Barría O, Fluxá P, Hott M, Martin C, Quezada C, Salazar-Onfray F. (2021) The Evaluation of 17 Gastrointestinal Tumor Markers Reveals Prognosis Value for MUC6, CK17, and CD10 in Gallbladder-Cancer Patients. Diagnostics (Basel) 11(2):153. doi: 10.3390/diagnostics11020153.
  10. Sebastián Alarcón, María de los Ángeles Toro, Carolina Villarreal, Rómulo Melo, Rodrigo Fernández, Ángel Ayuso Sacido, Daniel Uribe, Rody San Martín, Claudia Quezada (2020). Decreased Equilibrative Nucleoside Transporter 1 (ENT1) Activity Contributes to the High Extracellular Adenosine Levels in Mesenchymal Glioblastoma Stem-Like Cells. Cells. 9(8): 1914.
  11. Gorjana Rackov, Giorgia Iegani, Daniel Uribe, Claudia Quezada, José A. Garcia-Sanz, Cristábal belda- Iniesta, Carmen Escobedo-Lucea, Augusto Silva, Víctor González-Rumayor, Ángel Ayuso-Sacido (2020). Nilo1 monoclonal antibody inhibits the growth of patient-derived glioblastoma stem cells. Differential sensitivity to Nilo 1 monoclonal antibody stratifies patient-derived glioblastoma cells. Front. Oncol. 2020. doi.org/10.3389/fonc.2020.01665.
  12. Torres Á, Muñoz K, Nahuelpán Y, R Sáez AP, Mendoza P, Jara C, Cappelli C, Suarez R, Oyarzún C, Quezada C, San Martín R. (2020) Intraglomerular Monocyte/Macrophage Infiltration and Macrophage-Myofibroblast Transition during Diabetic Nephropathy Is Regulated by the A2B Adenosine Receptor. Cells 9(4):1051. doi: 10.3390/cells9041051.
  13. Cappelli C, Tellez A, Jara C, Alarcón S, Torres A, Mendoza P, Podestá L, Flores C, Quezada C, Oyarzún C, San Martín R. (2020) The TGF-β profibrotic cascade targets ecto-5′-nucleotidase gene in proximal tubule epithelial cells and is a traceable marker of progressive diabetic kidney disease. Biochim Biophys Acta Mol Basis Dis. 1866(7):165796. doi: 10.1016/j.bbadis.2020.165796.
  14. Touma J, Navarro M, Sepúlveda B, Pavon A, Corsini G, Fernández K, Quezada C, Torres A, Larrazabal-Fuentes MJ, Paredes A, Neira I, Ferrando M, Bruna F, Venegas A, Bravo J. (2020) The Chemical Compositions of Essential Oils Derived from Cryptocarya alba and Laurelia sempervirens Possess Antioxidant, Antibacterial and Antitumoral Activity Potential. Molecules 25(23):5600. doi:

10.3390/molecules25235600.

  1. Torres A, Erices J.I, Ehrenfeld I.P., Sanchez F., Virolle T., Uribe U., Rocha D., Niechi I., Ramirez M., San Martín R., and Quezada C. (2019) Extracellular Adenosine controls the cell migration/invasion of Glioblastoma Stem-like Cells through the activation of A3 Adenosine Receptor under Hypoxia. Cancer Letters 446:112-12.
  2. Alarcón S, Niechi I, Toledo F, Sobrevia L, Quezada C. (2019) Glioma progression in diabesity. Mol Aspects Med. 66:62-70.
  3. Guequén A, Zamorano P, Aguilar G, Córdova F, Boric M, Durán W, Salazar-Onfray F., Quezada C, Ehrenfeld P, Sarmiento J, Sánchez F. (2019) Interleukin 8 from glioblastoma-cell line U87 induces microvascular hyperpermeability through S-nitrosylation of p120 and VE-cadherin. Front Physiol. 10:988
  4. Garrido W, Jara C, Torres A, Suarez R, Cappelli C, Oyarzún C, Quezada C, San Martín R. (2019) Blockade of the Adenosine A3 Receptor Attenuates Caspase 1 Activation in Renal Tubule Epithelial Cells and Decreases Interleukins IL-1β and IL-18 in Diabetic Rats. Int J Mol Sci. 20(18). pii: E4531.
  5. Niechi I, Uribe-Ojeda A, Erices JI, Torres Á, Uribe D, Rocha JD, Silva P, Richter HG, San Martín

R, Quezada C. Adenosine Depletion as A New Strategy to Decrease Glioblastoma Stem-Like CellsAggressiveness. Cells. 2019; 8(11). pii: E1353. (ISI: 6.0) 20. Quezada C, Torres Á, Niechi I, Uribe D, Contreras-Duarte S, Toledo F, San Martín R, Gutiérrez J,Sobrevia L. (2018) Role of extracellular vesicles in glioma progression. Mol Aspects Med. 60:38-51. doi: 10.1016/j.mam.2017.12.003.

  1. Rocha, R., Torres, A., Ojeda, K., Uribe, D., Rocha, D., Erices, J.I., Niechi, I., San Martín, R., and Quezada, C. (2018) The Adenosine A3 Receptor regulates differentiation of Glioblastoma Stem-like Cells to Endothelial Cells under Hypoxia. International Journal Molecular Sciences 19(4).
  2. José Ignacio Erices, Ángelo Torres, Ignacio Niechi, Isabel Bernales and Claudia Quezada. (2018) Current Natural therapies in the treatment against Glioblastoma. Phytotherapy Research 32(11):2191- 2201
  3. Ángelo Torres, Valentina Arriagada, José Ignacio Erices, Maria de los Angeles Toro, Ignacio Niechi, Carlos Oyarzun and Claudia Quezada (2018) FK506 attenuates the MRP1-mediated chemoresistant phenotype in Glioblastoma stem like cells. International Journal Molecular Sciences 11;19(9).
  4. Torres ÁS, Erices JI, Uribe DA, Howden J, Niechi I, Muñoz S, San Martín R, Quezada C. (2017) Current Therapeutic Alternatives and New Perspectives in Glioblastoma Multiforme. Curr Med Chem. 24(25):2781-2795.
  5. Uribe D, Torres A, Rocha JD, Niechi I, Oyarzún O., Sobrevia L, San Martín R, Quezada C. (2017). Chemoresistance in glioblastoma stem-like cells: role of the hypoxic microenvironment and adenosine signaling. Mol Aspects Med. 55:140-151. (ISI 10.6).
  1. Oyarzún C, Garrido W, Alarcón S, Yáñez A, Sobrevia L, Quezada C, San Martín R. (2017). Adenosine Contribution to Normal Renal Physiology and Chronic Kidney Disease. Mol Aspects Med. 55:75-89. (ISI 10.6).
  1. Sebastián Alarcón, Wallys Garrido, Claudio Cappelli, Raibel Suárez, Carlos Oyarzún, Claudia Quezada, Rody San Martín. (2017) Deficient insulin-mediated upregulation of the equilibrative nucleoside transporter 2 contributes to chronically increased adenosine in diabetic glomerulopathy. Sci Rep. 7(1):9439. (ISI: 4.609).
  1. Roberto Villalobos-Labra, Luis Silva, Mario Subiabre, Joaquín Araos, Rocío Salsoso, Bárbara Fuenzalida, Tamara Sáez, Fernando Toledo, Marcelo Gonzalez, Claudia Andrea Quezada, Fabian Pardo, Delia Indira Chiarello, Andrea Leiva and Luis Sobrevia. (2017) Akt/mTOR role in human foetoplacental vascular insulin resistance in diseases of pregnancy. J Diabetes Res. 2017:5947859.
  1. Torres A, Vargas Y, Uribe D, Jaramillo C, Arriagada V, Salazar F, López M., Melo R., Oyarzún C, San Martín R and Quezada C. (2016) Adenosine A3 Receptor Elicits Chemoresistance Mediated by thMultiple Resistance-associated Protein-1 in Human Glioblastoma Stem-like Cells.Oncotarget 7(41):67373-67386.
  2. Torres A, Vargas Y, Uribe D, Carrasco C, Torres C, Oyarzún C, San Martín R and Quezada C. (2016) Pro-apoptotic and Anti-angiogenic Properties of the α/β Thujone Fraction from Thuja occidentalis on Glioblastoma Cells. J Neurooncol. 128(1):9-19. (ISI: 2.6).
  3. Kretschmar C, Oyarzún C, Villablanca C, Jaramillo C, Alarcón S, Perez G, Díaz-Encarnación MM, Pastor-Anglada M, Garrido W, Quezada C, San Martín R. (2016) Reduced Adenosine Uptake and Its Contribution to Signaling that Mediates Profibrotic Activation in Renal Tubular Epithelial Cells. PLoS One. 11(1):e0147430.
  4. Oyarzún C, Salinas C, Gómez D, Jaramillo K, Pérez G, Podestá L, Flores C, Quezada C, San Martín R. (2015) Increased levels of adenosine and CD73 activity precedes renal dysfunction in diabeticrats. Biochemistry Biophysical Research Communication 4; 468(1-2):354-9. (ISI: 2.455).
  5. Garrido W., Rocha JD; Otth C.; Oyarzún C.; San Martín R. Quezada C. (2014) Chemoresistance in high-grade gliomas: Relevance of the multidrug resistance-associated protein 1 and adenosina. Current Drug Targets; 15(10):931-42.
  6. Quezada C, Garrido W, Oyarzún C, Fernández K, Segura R, Melo R, Casanello P, Sobrevia L, San Martín R. (2013) 5′-ectonucleotidase mediates multiple-drug resistance in glioblastoma multiforme cells. J Cell Physiol. 228(3):602-8. (ISI:4.0)
  7. Quezada C, Alarcón S, Jaramillo C, Muñoz D, Oyarzún C, San Martín R. (2013) Targeting Adenosine Signaling to Treatment of Diabetic Nephropathy. Current Drug Targets. 14(4):490-6.
  8. Cárdenas A, Toledo C, Oyarzún C, Sepúlveda A, Quezada C, Guillén-Gómez E, Díaz- Encarnación MM, Pastor-Anglada M, San Martín R. (2013) Adenosine A(2B) receptor-mediate VEGF induction promotes diabetic glomerulopathy. Lab Invest. ; 93(1):135-44.
  9. Marín N, Zamorano P, Carrasco R, Mujica P, González FG, Quezada C, Meininger CJ, Boric MP, Durán WN, Sánchez FA. (2012). S-Nitrosation of β-catenin and p120 catenin: a novel regulatory mechanism in endothelial hyperpermeability. Circ Res. 17; 111(5):553-63.
  10. Villalba M, Hott M, Martin C, Aguila B, Valdivia S, Quezada C, Zambrano A, Concha MI, Otth C. (2012) Herpes simplex virus type 1 induces simultaneous activation of Toll-like receptors 2 and 4 and expression of the endogenous ligand serum amyloid A in astrocytes. Med. Microbiol. Immunol. 201(3):371-9.
  11. Quezada C, Alarcón S., Carcamo JG, San Martín R. (2011). The Activity of the Multidrug Resistance-Associated Protein 1 (MRP1) is increased in Kidney Glomeruli of Diabetic Rats. Biol.Chem. 392(6):529-37.
  12. Claudia Quezada, Lilia Peigñan, Rodrigo Segura, Francisco Riquelme, Rómulo Melo, David Rojas, Freddy Ayach, Rody San Martín, Juan Guillermo Cárcamo (2011). Glioblastomas multiformes en Chile y su relación con resistencia múltiple a drogas. Revista Médica de Chile, 139:415-424.
  13. Lilia Peigñan, Wallys Garrido, Rodrigo Segura, Rómulo Melo, David Rojas, Juan Guillermo Cárcamo, Rody San Martín 1, Claudia Quezada (2011). Combined Use of Anticancer Drugs and An Inhibitor of Multiple Drug Resistance-Associated Protein-1 Increases Sensitivity and DecreasesSurvival of Glioblastoma Multiforme Cells in vitro. Neurochemical research, 36(8): 1397-1406.
  14. Garrido W. Muñoz M., San Martín R., Quezada C (2011). FK506 Confers Chemosensitivity to Anticancer Drugs in Glioblastoma Multiforme Cells by Decreasing the Expression of the Multiple Resistance-Associated Protein-1. Biochemistry Biophysical Research Communication, 411(1): 62-68.
  15. Prieto C, Krause B, Quezada C, San Martin R, Sobrevia L, Casanello P. (2011) Hypoxia-reduced nitric oxide synthase activity is partially explained by higher arginase-2 activity and cellularredistribution in human umbilical vein endothelium. Placenta. 32(12):932-40.
  16. Juan Guillermo Cárcamo, Marcelo N. Aguilar, Claudia A. Barrientos, Constanza F. Carreño, Claudia A. Quezada, Carlos Bustos, René A. Manríquez, Rubén Avendaño-Herrera, Alejandro J. Yañez (2011). Effect of emamectin benzoate on transcriptional expression of cytochromes P450 and the multidrug transporters (Pgp and MRP1) in rainbow trout (Oncorhynchus mykiss) and the sea lice Caligus rogercresseyi. Aquaculture, 321: 207–215.
  17. Rauch MC, San Martín A, Ojeda D, Quezada C, Salas M, Cárcamo JG, Yañez AJ, Slebe JC, Claude (2009). Tacrolimus causes a blockage of protein secretion which reinforces its immunosuppressive activity and also explains some of its toxic side-effects. Transpl Immunol. 22(1-2):72-81.
  18. Roa H, Gajardo C, Troncoso E, Fuentealba V, Escudero C, Yáñez A, Sobrevia L, Pastor-Anglada M, Quezada C, San Martin R.(2009) Adenosine mediates transforming growth factor-beta 1 release in kidney glomeruli of diabetic rats. FEBS Lett. 583(19):3192-8.
  19. Quezada C., Garrido W, González-Oyarzún M, Rauch M.C., Salas M, San Martín R., Claude A., Yañez A., Slebe J.C. and Cárcamo J.G. (2008) Effect of tacrolimus on activity and expression of Pgp and ABCA5 proteins in hematoencephalic barrier cells. Biological and PharmaceuticalBulletin, 31(10) 1911-1916.
  20. Valladares D, Quezada C, Montecinos P, Concha II, Yañez AJ, Sobrevia L, San Martín R. (2008) “Adenosine A(2B) receptor mediates an increase on VEGF-A production in rat kidney glomeruli”. Biochemistry Biophysical Research Communication, 366(1):180-185.
  21. San Martín R, Hurtado W, Quezada C, Molina A, Álvarez M, Vera MI, Reyes A and Krauskopf M. (2007) “The prolactin receptor gene of carp fish: structure, promoter characterization and expression of short forms”. Journal of Cell Biochemistry 100(4):970-980.
  22. Marco Álvarez, Claudia Quezada, Alfredo Molina, Manuel Krauskopf, M. Inés Vera and Marc Thiry. (2006) “Ultrastructural changes of the carp hepatocyte nucleolus during seasonalacclimatization”. Biological Cell, 98(8):457-63.
  23. Quezada, C., Navarro, C., San Martín, R., Molina, A., Álvarez, M., Bachellerie, J.P., Ganot, P., Krauskopf, M., and Vera, M.I. (2006) “Genomic organization of nucleolin gene in a teleost fish”. Biological Research, 39 (2): 353-365. 4.2.
  24. Quezada C., Pinto R., Krauskopf , M., Vera, M.I. (2004). “Euritermal fish acclimatization and nucleolar function: a review”. J. Thermal Biology, 29: 663-667.
  25. Alvarez, M., Quezada, C., Navarro, C., Molina, A., Bouvet, P., Krauskopf, M., Vera, M.I. (2003) “An increased expression of nucleolin is associated with physiological nucleolar segregation”. Biochem Biophys Res Commun. (1) 301:152-8.
  26. Vera, M.I., Molina, A., Pinto, R., Reyes, M., Alvarez, M., Krauskopf, E., Quezada, C., Torres, J., Krauskopf, M. (2003) “Genomic organization of the rDNA cistrón of the teleost fish Cyprinuscarpio” Biol. Res., 36: 1-11.
  27. Vera, M.I., Kausel, G., Barrera, R., Leal, S., Figueroa, J. and Quezada, C. (2000) “Seasonal adaptation modulates the expression of the protein kinase CK2 beta subunit gene in the carp”Biochem Biophys Res Comun. 271 (3): 735-40.
  28. Sarmiento, J., Leal, S., Quezada, C., Kausel, G., Figueroa, J., Vera, M.I., Krauskopf, M. (2000)”Environmental acclimatization of the carp modulates the transcription of b-actin”. J. Cell.Biochem, 80: 223-228

 

Book Chapter

Cárcamo JG, Quezada CA, González-Oyarzún M. (2009) Membrane Transporters and Receptors in

Disease. Multidrug resistance proteins. 2009: 153-170, ISBN: 978-81-308-0330-2 Editors: Luis

Sobrevia and Paola Casanello

 

Research lines

-Mechanisms of chemo- and radioresistance to treatment in cancer

-Studies of cell invasion and migration in cancer

-Liquid biopsies and extracellular vesicles

-Characterization and subtypes of cancer stem cells

-Clinical trials and personalized therapies in cancer