1. Gallbladder cancer. Roa JC, García P, Kapoor VK, Maithel SK, Javle M, Koshiol J. Juan Carlos Roa Strauch. Nat Rev Dis Primers. 10.1038/s41572-022-00398-y.

2. c-Abl kinase at the crossroads of healthy synaptic remodeling and synaptic dysfunction in neurodegenerative diseases. Gutiérrez DA, Chandía-Cristi A, Yáñez MJ, Zanlungo S, Álvarez AR(*). Regeneration Research 10.4103/1673-5374.346540.

3. Oxidized High-Density Lipoprotein Induces Endothelial Fibrosis Promoting Hyperpermeability, Hypotension, and Increased Mortality. Rojas M, Prado Y, Tapia P, Carreño LJ, Cabello-Verrugio C, Simon F. Antioxidants. 10.3390/antiox11122469.

4. In Vivo and in vitro antitumor activity of tomatine in hepatocellular carcinoma. Echeverría C, Martin A, Simon F, Salas CO, Nazal M, Varela D, Pérez-Castro RA, Santibanez JF, Valdés-Valdés RO, Forero-Doria O, Echeverría J. Frontiers in Pharmacology. 10.3389/fphar.2022.1003264.

5. Bile Acids Induce Alterations in Mitochondrial Function in Skeletal Muscle Fibers. Abrigo J, Olguín H, Gutierrez D, Tacchi F, Arrese M, Cabrera D, Valero-Breton M, Elorza AA, Simon F, Cabello-Verrugio C. Antioxidants. 10.3390/antiox11091706.

6. Combined Administration of Andrographolide and Angiotensin- (1-7) Synergically Increases the Muscle Function and Strength in Aged Mice. Abrigo J, Simon F, Cabrera D, Vilos C, Cabello-Verrugio C. Felipe Alonso Simon Pino. CURRENT MOLECULAR MEDICINE. 10.2174/1566524021666211207112106.

7. Intensive care unit-acquired weakness: A review from molecular mechanisms to its impact in COVID-2019. Gonzalez A, Abrigo J, Achiardi O, Simon F, Cabello-Verrugio C. European Journal of Translational Myology. 10.4081/ejtm.2022.10511.

8. Regulatory Mechanisms of Muscle Mass: The Critical Role of Resistance Training in Children and Adolescent. Castelli F, Valero-Breton M, Hernandez M, Guarda F, Cornejo J, Cabello-Verrugio C, Cabrera D. Advances in Experimental Medicine and Biology. 10.1007/5584_2022_743.

9. Adapt to Persist: Glioblastoma Microenvironment and Epigenetic Regulation on Cell Plasticity. Uribe, D., Niechi, I., Rackov, G., Erices, J. I., San Martín, R., & Quezada, C. José Erices Rodríguez. Biology (Basel). 10.3390/biology11020313.

10. A2B Adenosine Receptor Enhances Chemoresistance of Glioblastoma Stem-Like Cells under Hypoxia: New Insights into MRP3 Transporter Function. Rocha, J. D., Uribe, D., Delgado, J., Niechi, I., Alarcón, S., Erices, J. I., Melo, R., Fernández-Gajardo, R., Salazar-Onfray, F., San Martín, R., & Quezada Monrás, C. International Journal of Molecular Sciences. 10.3390/ijms23169022.

11. Amyloid ß-Peptide Causes the Permanent Activation of CaMKIIa through Its Oxidation. Picón-Pagès P, Fanlo-Ucar H, Herrera-Fernández V, Ausellé-Bosch S, Galera-López L, Gutiérrez DA, Ozaita A, Álvarez AR, Oliva B, Muñoz FJ. International Journal of Molecular Sciences. 10.3390/ijms232315169.

12. The c-Abl/p73 pathway induces neurodegeneration in a Parkinson’s disease model. Marín T, Valls C, Jerez c, Huerta T, Elgueta D, Vidal RL, Alvarez AR(*), Cancino GI (*). Neuroscience Reports. 10.1016/j.ibneur.2022.10.006.

13. Neuronopathic Gaucher disease: Beyond lysosomal dysfunction. Arévalo NB, Lamaizon CM, Cavieres VA, Burgos PV, Alvarez AR, Yañez MJ(*), Zanlungo S(*). Frontiers in Molecular Neuroscience. 10.3389/fnmol.2022.934820.

14. Surface enhanced fluorescence effect improves the in vivo detection of amyloid aggregates. Cabrera P, Jara-Guajardo P, Oyarzún MP, Parra-Muñoz N, Campos A, Soler M, Álvarez A, Morales-Zavala F, Araya E, Minniti AN, Aldunate R, Kogan MJ(*). Nanomedicine: Nanotechnology, Biology and Medicine. 10.1016/j.nano.2022.102569.

15. c-Abl activation linked to autophagy-lysosomal dysfunction contributes to neurological symptoms of Niemann-Pick type A disease. Marín T, Dulcey AE, Campos F, De la Fuente C, Acuña M, Castro J, Pinto C, Yáñez MJ, Cortez C, McGrath DW, Sáez PJ, Gorshkov K, Zheng W, Southall NT, Fonseca C, Marugan JJ(*), Alvarez AR(*), Zanlungo S (*) Tamara Alejandra Marin Marin. Frontiers in Cell and Developmental Biology. 10.3389/fcell.2022.844297.

16. Host-virus relationships: a sum of many battles. López-Lastra M. Open Bio. 10.1002/2211-5463.13420.

17. The low affinity A2B adenosine receptor enhances migratory and invasive capacity in vitro and angiogenesis in vivo of glioblastoma stem-like cells. Erices, J. I., Niechi, I., Uribe-Ojeda, A., Toro, M. L. Á., García-Romero, N., Carrión-Navarro, J., Monago-Sánchez, Á., Ayuso-Sacido, Á., Martin, R. S., & Quezada-Monrás, C. Frontiers in Oncology. 10.3389/fonc.2022.969993.

18. Modulation of immune cells as a therapy for cutaneous lupus erythematosus. Soto JA, Melo F, Riedel CA, Bueno SM, Kalergis AM. International Journal of Molecular sciences. 10.3390/ijms231810706.

19. Inactivated Vaccine-induced SARS-CoV-2 Variant-Specific Immunity in Children. Soto JA, Melo F, Gutierrez C, Schulz BM, Berríos RV, Rivera D, Piña A, Hoppe G, Duarte L, Vásquez Y, Moreno D, Ríos M, Palacios P, García R, Santibañez A, Pacheco G, Méndez C, Andrade C, Silva P, Diethelm B, Astudillo P, Calvo M, Cárdenas A, González M, Goldsack M, Gutierrez V, Potin M, Schilling A, Tapia L, Twelee L, Villena R, Grifoni A, Sette A, Weiskopf, Fasce R, Fernandez J, Mora J, Ramírez E, Gaete A, Acevedo M, Valiente F, Soto-rifo R, Retamal A, Muñoz N, Meng X, Xin Q, Alarcon Q, Gonzalez JV, Le Corre N, Álvarez MJ, Gonzalez PA, Abarca K, Perret C, Carreño L, Bueno SM, Kalergis AM. American society for microbiolgy. 10.1128/mbio.01311-22.

20. Safety and Immunogenicity of an Inactivated Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine in a Subgroup of Healthy Adults in Chile. Bueno SM, Abarca K, González PA, Gálvez NMS, Soto JA, Duarte LF, Schultz BM, Pacheco GA, González LA, Vásquez Y, Ríos M, Melo-González F, Rivera-Pérez D, Iturriaga C, Urzúa M, Domínguez A, Andrade CA, Berríos-Rojas R, Canedo G, Covián C, Moreno D, Saavedra F, Vallejos OP, Donato P, Espinoza P, Fuentes D, González M, Guzmán P, Muñoz P, Pérez CM, Potin M, Rojas A, Fasce RA, Fernández J, Mora J, Ramírez E, Gaete A, Oyarzún A, Valiente F, Soto-Rifo R, Wiskopf D, Sette A, Zeng G, Meng W, González JV, Kalergis AM. Clinical Infectious Disease. 10.1093/cid/ciab823.

21. Involvement of trained immunity during autoimmune responses. Mora V, Loaiza R, Soto JA, Bohmwald K, Kalergis AM. Journal of autoimmunity. 10.1016/j.jaut.2022.102956.

22. Female offspring gestated in hypothyroxinemia and infected with human Metapneumovirus (hMPV) suffer a more severe infection and have a higher number of activated CD8+ T lymphocytes. Funes SC, Ríos M, Fernández-Fierro A, Rivera-Pérez D, Soto JA, Valbuena JR, Altamirano-Lagos MJ, Gómez-Santander F, Jara EL, Zoroquiain P, Roa JC, Kalergis AM, Riedel CA. Frontiers in immunology. 10.3389/fimmu.2022.966917.

23. Risk Factors from Pregnancy to Adulthood in Multiple Sclerosis Outcome. González-Madrid E, Rangel-Ramírez MA, Mendoza-León MJ, Álvarez-Mardones O, González PA, Kalergis AM, Opazo MC, Riedel CA. International journal of molecular sciences. 10.3390/ijms23137080.

24. Contribution of Gut Microbiota to Immune Tolerance in Infants. Mendez CS, Bueno SM, Kalergis AM. Journal of Immunology Research. 10.1155/2021/7823316.

25. Potential Neurocognitive Symptoms Due to Respiratory Syncytial Virus Infection. Andrade CA, Kalergis AM, Bohmwald K. Pathogens. 10.3390/pathogens11010047.

26. Trained immunity contribution to autoimmune and inflammatory disorders. Funes S, Rios M, Fernández A, Di Genaro MS, Kalergis AM. Frontiers in immunology. 10.3389/fimmu.2022.868343.

27. Neurotrophin Signaling Impairment by Viral Infections in the Central Nervous System. Bohmwald K, Andrade CA, Mora VP, Muñoz JT, Ramirez R, Rojas MF, Kalergis AM. International Journal of Molecular sciences. 10.3390/ijms23105817.

28. Influence of online opinions and interactions on the covid-19 vaccination in Chile. Villegas C, Ortiz A, Arriagada V, Ortega S, Walker J, Arriagada E, Kalergis AM, Huepe C. Scientific Reports. 10.1038/s41598-022-23738-0.

29. Durability of AZD1222 and hybrid humoral immunity against omicron BA.1 and BA.4. Soto-Rifo, R.Lancet Infectious Diseases. 10.1016/S1473-3099(22)00667-3.

30. Epitranscriptomic regulation of HIV-1 full-length RNA packaging. Pereira-Montecinos C, Toro-Ascuy D, Ananías-Sáez C, Gaete-Argel A, Rojas-Fuentes C, Riquelme-Barrios S, Rojas-Araya B, García-de-Gracia F, Aguilera-Cortés P, Chnaiderman J, Acevedo ML, Valiente-Echeverría F, Soto-Rifo R. Nucleic Acids Research. 10.1093/nar/gkac062.

31. Identification of VEGFR2 as the Histatin-1 receptor in endothelial cells. Mateluna C, Torres P, Rodriguez-Peña M, Silva P, Matthies DJ, Criollo A, Bikker FJ, Bolscher JGM, Wilson CAM, Zapata-Torres G, Torres VA. Biochemical Pharmacology. 10.1016/j.bcp.2022.115079.

32. «The Sall2 transcription factor promotes cell migration regulating focal adhesion turnover and integrin ß1 expression». Riffo E, Palma M, Hepp MI, Benítez-Riquelme D, Torres VA, Castro AF, Pincheira R. Frontiers in Cell and Developmental Biology. 10.3389/fcell.2022.1031262.

33. BCG vaccination induces cross-protective immunity against pathogenic microorganisms. Soto JA, Gálvez NMS, Andrade CA, Ramírez MA, Riedel CA, Kalergis AM, Bueno SM. Trends in Immunology. 10.1016/j.it.2021.12.006.

34. Role of Extracellular Trap Release During Bacterial and Viral Infection. Schultz BM, Acevedo OA, Kalergis AM, Bueno SM. Frontiers in Microbiology. 10.3389/fmicb.2022.798853.

35. Bioinformatic and experimental characterization of SEN1998: a conserved gene carried by the Enterobacteriaceae-associated ROD21-like family of genomic islands. Piña-Iturbe A, Hoppe-Elsholz G, Fernández PA, Santiviago CA, González PA, Bueno SM Susan. Scientific Reports. 10.1038/s41598-022-06183-x.

36. Polypyrimidine-Tract-Binding Protein Isoforms Differentially Regulate the Hepatitis C Virus Internal Ribosome Entry Site. Angulo, J., Cáceres, C.J., Contreras N., Fernández-García, L.,Chamond, N, Ameur, M., Sargueil, B., López-Lastra, M. Viruses. 10.3390/v15010008.

37. RNA-Binding Proteins as Regulators of Internal Initiation of Viral mRNA Translation. López-Ulloa B, Fuentes Y, Pizarro-Ortega MS, López-Lastra M. Viruses. 10.3390/v14020188.

38. Federation of clinical immunology societies goes south 2021, advanced course on molecular and cellular translational immunology. Diethelm B, Reyes A,Rosenstein Yvonne, Kalil J, Hill M, Docena G, Anegon I, González PA, Kalergis AM. Immunotherapy. 10.2217/imt-2022-0075.

39. BCG-Based vaccines elicit antigen-specific adaptative and trained immunity against SARS-CoV-2 and Andes orthohantavirus. Soto JA, Díaz FE, Retamal A, Gálvez NMS, Melo F, Piña A, Ramírez MA, Bohmwald K, González PA, Bueno SM, Kalergis AM. Vaccines (Basel). 10.3390/vaccines10050721.

40. From animal studies into clinical trials: the relevance of animal models to develop vaccines and therapies to reduce disease severity and prevent hRSV infection. Soto JA, Gálvez NMS, Rivera DB, Díaz FE, Riedel CA, Bueno SM, Kalergis AM. Expert opinion on drug Discovery. 10.1080/17460441.2022.2123468.

41. Safety and Non-Inferiority Evaluation of Two Immunization Schedules with an Inactivated SARS-CoV-2 Vaccine in Adults: A Randomized Clinical Trial. Abarca K, Iturriaga C, Urzúa M, Le corre N, Pineda A, Fernandez C, Domínguez A, González PA, Bueno SM, Donato P, Espinoza P, Fuentes D, González M, Guzman P, Muñoz P, Pérez C, Potin M, Rojas A, Gonzalez JV, Gálvez NMS, Aguirre F, Aljaro S, Batiz LF, Campisto Y, Cepeda M, Cortés A, López S, Pérez ML, Schilling A, Kalergis AM. Vaccines (Basel). 10.3390/vaccines10071082.

42. A Booster Dose of CoronaVac Increases Neutralizing Antibodies and T Cells that Recognize Delta and Omicron Variants of Concern. Schultz B, Melo F, Duarte L, Galvez NMS, Pacheco G, Soto JA, Berríos R, Gonzalez LA, Moreno D, Rivera D, Ríos M, Vásquez Y, Hoppe G, Andrade CA, Vallejos OP, Piña A, Iturriaga C, Urzua M, Navarrete MS, Rojas A, Fasce R, Fernandez J, Mora J, Ramirez E, Gaete A, Acevedo ML, Valiente F, Soto-Rifo R, Weiskopf D, Grifoni A, Sette A, Zeng G, Meng W, González JV, González PA, Abarca K, Kaleris AM, Bueno SM. American society for microbiolgy. 10.1128/mbio.01423-22.

43. Differences in the immune response elicited by two immunization schedules with an inactivated SARS-CoV-2 vaccine in a randomized phase 3 clinical trial. Galvez NMS, Pacheco G, Schultz BM, Melo F, Soto JA, Duarte LF, González LA, Rivera D, Rios M, Berrios R, Vásquez Y, Moreno D, Vallejos O, Andrade CA, Hoppe G, Iturriaga C, Urzua M, Navarrete MS, Rojas A, Fasce R, Fernandez J, Mora J, Ramirez E, Gaete A, Acevedo M, Valiente F, Soto-Rifo R, Weiskopf D, Grifoni A, Sette Zeng, Meng Wing, González JV, Jonhson M, Goldblatt D, González PA, Abarca K, Bueno SM, Kalergis AM. ELife. 10.7554/eLife.81477.

44. Contribution of two-dose vaccination toward the reduction of COVID-19 cases, ICU hospitalizations and deaths in chile assessed through explanatory generalized additive models for location, scale and shape . Reyes H, Diethelm B, Méndez C, Rebolledo D, Lillo B, Muñoz SR, Bueno SM, González PA, Kalergis AM. Frontiers in immunology. 10.3389/fpubh.2022.815036.

45. Aging envisage imbalance of the periodontium: A keystone in oral disease and systemic health. Villalobos V, Garrido M, Reyes A, Fernández C, Diaz C, Torres VA, González PA, Cáceres M. Frontiers in immunology. 10.3389/fimmu.2022.1044334.

46. The Emerging Role of PIWI-Interacting RNAs (piRNAs) in Gastrointestinal Cancers: An Updated Perspective. Riquelme I, Pérez-Moreno P, Letelier P, Brebi P, Roa JC. Cancers. 10.3390/cancers14010202.

47. Neutralizing antibodies induced by homologous and heterologous boosters in CoronaVac vaccinees in Chile. Acevedo J, Acevedo ML, Gaete-Argel A, Araos R, Gonzalez C, Espinoza D, Rivas S, Pizarro P, Jarpa S, Soto-Rifo R, Jara A, Valiente-Echeverría F. Clinical Microbiology and Infection. 10.1016/j.cmi.2022.11.017.

48. The double-stranded RNA-binding protein, Staufen1, is an IRES-transacting factor regulating HIV-1 cap-independent translation initiation. Ramos H, Monette A, Niu M, Barrera A, López-Ulloa B, Fuentes Y, Guizar P, Pino K, DesGroseillers L, Mouland AJ, López-Lastra M. Nucleic Acids Research. 10.1093/nar/gkab1188.

49. LDL particle size and antioxidant HDL function improve after sustained virological response in patients with chronic HCV. Vargas JI, Rivera K, Arrese M, Benitez C, Barrera F, Hugo M, Arab JP, Pino K, Barrera A, Lopez-Lastra M, Rigotti A, Soza A. Annal of Hepatology. 10.1016/j.aohep.2021.100555.

50. Relationship between endothelial and angiogenesis biomarkers envisage mortality in a prospective cohort of COVID-19 patients requiring respiratory support. Maldonado F, Morales D, Díaz-Papapietro C, Valdés C, Fernandez C, Valls N, Lazo M, Espinoza C, González R, Gutiérrez R, Jara A, Romero C, Cerda O, Cáceres M. Frontiers in medicine. 10.3389/fmed.2022.826218.

51. Is There a Role for Heat Shock Factor in Viral Infections? Antonia Reyes, Areli J. Navarro, Benjamín Diethelm, Alexis M. Kalergis, Pablo A. González. FEBS Open Bio. 10.1002/2211-5463.13419.

52. Role of Epitranscriptomic and Epigenetic Modifications during the Lytic and Latent Phases of Herpesvirus Infections. Soto AA, Ortiz G, Contreras S, Soto-Rifo R, González PA. Microorganisms. 10.3390/microorganisms10091754.

53. Environmental and Lifestyle Risk Factors in the Carcinogenesis of Gallbladder Cancer. Pérez-Moreno P, Riquelme I, García P, Brebi P, Roa JC. Journal of Personalized Medicine. 10.3390/jpm12020234.

54. Gallbladder reporting and data system (GB-RADS) for risk stratification of gallbladder wall thickening on ultrasonography: an international expert consensus. Gupta P, Dutta U, Rana P, Singhal M, Gulati A, Kalra N, Soundararajan R, Kalage D, Chhabra M, Sharma V, Gupta V, Yadav TD, Kaman L, Irrinki S, Singh H, Sakaray Y, Das CK, Saikia U, Nada R, Srinivasan R, Sandhu MS, Sharma R, Shetty N, Eapen A, Kaur H, Kambadakone A, de Haas R, Kapoor VK, Barreto SG, Sharma AK, Patel A, Garg P, Pal SK, Goel M, Patkar S, Behari A, Agarwal AK, Sirohi B, Javle M, Garcea G, Nervi F, Adsay V, Roa JC, Han HS. Abdominal Radiology. 10.1007/s00261-021-03360-w.

55. Mucocutaneous Manifestations in Autoimmune Gastritis: A Prospective Case-Control Study. Gonzalez A, Latorre G, Paredes L, Montoya L, Maquilon S, Shah SC, Espino A, Sabatini N, Torres J, Roa JC, Riquelme A, Kolbach M. The American Journal of Gastroenterology. 10.14309/ajg.0000000000001501.

56. Interplay between Lipid Metabolism, Lipid Droplets, and DNA Virus Infections. Mónica A. Farías, Benjamín Diethelm-Varela, Areli J. Navarro, Alexis M. Kalergis, and Pablo A. González. Cells. 10.3390/cells11142224.

57. Pharmacological Inhibition of IRE-1 Alpha Activity in Herpes Simplex Virus Type 1 and Type 2-Infected Dendritic Cells Enhances T Cell Activation. Tognarelli EI, Retamal-Díaz A, Farías MA, Duarte LF, Palomino TF, Ibañez FJ, Riedel CA, Kalergis AM, Bueno SM, González PA. Frontiers in immunology. 10.3389/fimmu.2021.764861.

58. Distal Consequences of Mucosal Infections in Intestinal and Lung Inflammation. Melo-González F, Sepúlveda-Alfaro J, Schultz BM, Suazo ID, Boone DL, Kalergis AM, Bueno SM. Frontiers in Immunology. 10.3389/fimmu.2022.877533.

59. Limited Heme Oxygenase Contribution to Modulating the Severity of Salmonella enterica serovar Typhimurium Infection. Sebastián VP, Moreno-Tapia D, Melo-González F, Hernández-Cáceres MP, Salazar GA, Pardo-Roa C, Farías MA, Vallejos OP, Schultz BM, Morselli E, Álvarez-Lobos MM, González PA, Kalergis AM, Bueno SM. Antioxidants. 10.3390/antiox11061040.

60. Non-capsular based immunization approaches to prevent Streptococcus pneumoniae infection. Silva PH, Vázquez Y, Campusano C, Retamal-Díaz A, Lay MK, Muñoz CA, González PA, Kalergis AM, Bueno SM. Frontiers in Cellular and Infection Microbiology. 10.3389/fcimb.2022.949469.

61. Differential neutralizing antibody responses elicited by CoronaVac and BNT162b2 against SARS-CoV-2 Lambda in Chile. Nature Microbiology. 10.1038/s41564-022-01092-1.

62. Reduced immune response to inactivated SARS-CoV-2 vaccine in a cohort of immunocompromised patients in Chile. Balcells ME, Le Corre N, Durán J, Ceballos ME, Vizcaya C, Mondaca S, Dib M, Rabagliati R, Sarmiento M, Burgos PI, Espinoza M, Ferrés M, Martinez-Valdebenito C, Ruiz-Tagle C, Ortiz C, Ross P, Budnik S, Solari S, Vizcaya MLÁ, Lembach H, Berrios-Rojas R, Melo-González F, Ríos M, Kalergis AM, Bueno SM, Nervi B. Clinical Infectious Diseases. 10.1093/cid/ciac167.

63 Identification of biomarkers for disease severity in nasopharyngeal secretions of infants with upper or lower respiratory tract viral infections. Bertrand PJ, Vázquez Y, Beckhaus AA, González LA, Contreras AM, Ferrés M, Padilla O, Riedel CA, Kalergis AM, Bueno SM. Clinical Experimental Immunology. 10.1093/cei/uxac083.

64. SARS-CoV-2 vaccine booster in solid organ transplant recipients previously immunised with inactivated versus mRNA vaccines: A prospective cohort study. Dib M, Le Corre N, Ortiz C, García D, Ferrés M, Martinez-Valdebenito C, Ruiz-Tagle C, Ojeda MJ, Espinoza MA, Jara A, Arab JP, Rabagliati R, Vizcaya C, Ceballos ME, Sarmiento M, Mondaca S, Viñuela M, Pastore A, Szwarcfiter V, Galdames E, Barrera A, Castro P, Gálvez NM, Soto JA, Bueno SM, Kalergis AM, Nervi B, Balcells ME. Lancet Regional Health – Americas. 10.1016/j.lana.2022.100371.

65. Genetic Variation in MicroRNA-423 Promotes Proliferation, Migration, Invasion, and Chemoresistance in Breast Cancer Cells. Morales-Pison S, Jara L, Carrasco V, Gutiérrez-Vera C, Reyes JM, Gonzalez-Hormazabal P, Carreño LJ, Tapia JC, Contreras HR. International Journal of Molecular Sciences. 10.3390/ijms23010380.

66. Editorial: Innate Immune Cells in the Control of Intracellular Bacteria. Balboa L, Baena A, Carreño LJ. Frontiers in Cellular and Infection Microbiology. 10.3389/fcimb.2022.830203.

67. Is there a role for herpes simplex virus type 1 in multiple sclerosis? Luisa F. Duarte, Sebastian Gatica, Almendra Castillo, Alexis M. Kalergis, Susan M. Bueno, Claudia A. Riedel, Pablo A. González. Microbes and Infection. 10.1016/j.micinf.2022.105084.

1. Asymptomatic Herpes Simplex Virus Type 1 Infection Causes an Earlier Onset and More Severe Experimental Autoimmune Encephalomyelitis Luisa F. Duarte, María J. Altamirano-Lagos, Jorge H. Tabares-Guevara, Ma. Cecilia Opazo, Máximo Díaz, Romina Navarrete, Catalina Muza, Omar P. Vallejos, Claudia A. Riedel, Susan M. Bueno, Alexis M. Kalergis and Pablo A. González, (2021), Frontiers in Immunology https://doi.org/10.3389/fimmu.2021.635257.

2. Impact of Hypoxia over Human Viral Infections and Key Cellular Processes. Antonia Reyes, Luisa F. Duarte, Mónica A. Farías, Eduardo Tognarelli, Alexis M. Kalergis, Susan M. Bueno and Pablo A. González, (2021). International Journal of Molecular Sciences. https://doi.org/10.3390/ ijms22157954.

3. Herpes simplex virus interference with immunity: Focus on dendritic cells. Mónica A. Farías, Duarte Luisa, Tognarelli Eduardo, Gonzalez Pablo, (2021). Virulence. https://doi.org/10.1080/21505594.2021.1980990.

4. Crosstalk Between Epithelial Cells, Neurons and Immune Mediators in HSV-1 Skin Infection. Luisa F. Duarte, Antonia Reyes, Mónica A. Farías, Claudia A. Riedel, Susan M. Bueno, Alexis M. Kalergis and Pablo A. González, (2021). Frontiers in Immunology. https://doi.org/10.3389/fimmu.2021.662234.

5. Modulation of Endosome Function, Vesicle Trafficking and Autophagy by Human Herpesviruses. Eduardo I. Tognarelli, Antonia Reyes, Nicolás Corrales, Leandro J. Carreño, Susan M. Bueno, Alexis M. Kalergis and Pablo A. González, (2021). Cells. https://doi.org/10.3390/cells10030542.

6. Therapeutic uses of natural astaxanthin: An evidence-based review focused on human clinical trials. Andrea Donoso, Javiera Gonzalez-Duran , Andres Agurto Munoz, Pablo A. Gonzalez, Cristian Agurto-Munoz, (2021). Pharmacological Research. https://doi.org/10.1016/j.phrs.2021.105479.

7. Characterization of the anti-inflammatory capacity of IL-10- producing neutrophils in response to Streptococcus pneumoniae infection, Frontiers in Immunology. 10.3389/fimmu.2021.638917. González LA, Melo-González F, Sebastian P, Vallejos OP, Noguera LP, Suazo IC, Schultz BM, Soto JA, Manosalva AH, Parker D, Riedel CA, González PA, Kalergis AM, Bueno SM, (2021).

8. Recognition of Variants of Concern by Antibodies and T Cells Induced by a SARS-CoV-2 Inactivated Vaccine, Frontiers in Immunology. 10.3389/fimmu.2021.747830. Melo-González F, Soto JA, González LA, Fernández J, Duarte LF, Schultz BM, Gálvez NMS, Pacheco GA, Ríos M, Vázquez Y, Rivera-Pérez D, Moreno-Tapia D, Iturriaga C, Vallejos OP, Berríos-Rojas RV, Hoppe-Elsholz G, Urzúa M, Bruneau N, Fasce RA, Mora J, Grifoni A, Sette A, Weiskopf D, Zeng G, Meng W, González-Aramundiz JV, González PA, Abarca K, Ramírez E, Kalergis AM, Bueno SM, (2021).

9. Serial Stimulation of Invariant Natural Killer T Cells with Covalently Stabilized Bispecific T-cell Engagers Generates Antitumor Immunity While Avoiding Anergy, Cancer Research. 10.1158/0008-5472.CAN-20-2219. Saavedra-Avila NA, Keshipeddy S, Guberman-Pfeffer MJ, Pérez-Gallegos A, Saini NK, Schäfer C, Carreño LJ, Gascón JA, Porcelli SA, Howell AR., (2021).

10. IL-10-Dependent Amelioration of Chronic Inflammatory Disease by Microdose Subcutaneous Delivery of a Prototypic Immunoregulatory Small Molecule. Jorge H. Tabares-Guevara, Julio C. Jaramillo , Laura Ospina-Quintero, Christian A. Piedrahita-Ochoa, Natalia Garcia-Valencia, David E. Bautista-Erazo, Erika Caro-Gomez, Camila Covian, Angello Retamal-Diaz, Luisa F. Duarte, Pablo A. Gonzalez, Susan M. Bueno, Claudia A. Riedel, Alexis M. Kalergis and Jose R. Ramirez-Pineda, (2021). Frontiers in Immunology. https://doi.org/10.3389/fimmu.2021.708955.

11. Induction of Trained Immunity by Recombinant Vaccines. Covián C, Ríos M, Berríos-Rojas RV, Bueno SM, Kalergis AM. , (2021). Front Immunol. doi:10.3389/fimmu.2020.611946.

12. Immune response during hantavirus diseases: implications for immunotherapies and vaccine design. Saavedra F, Díaz FE, Retamal-Díaz A, Covián C, González PA, Kalergis AM, (2021). Immunology. doi: 10.1111/imm.13322.

13. Contribution of Pro-Inflammatory Molecules Induced by Respiratory Virus Infections to Neurological Disorders. Bohmwald K, Andrade CA, Kalergis AM, (2021). Pharmaceuticals (Basel). doi: 10.3390/ph14040340.

14. Safety and Immunogenicity of an Inactivated SARS-CoV-2 Vaccine in a Subgroup of Healthy Adults in Chile., Clinical Infectious Diseases. 10.1093/cid/ciab823. Bueno SM*, Abarca K, González PA, Gálvez NMS, Soto JA, Duarte LF, Schultz BM, Pacheco GA, González LA, Vázquez Y, Ríos M, Melo-González F, Rivera-Pérez D, Iturriaga C, Urzúa M, Domínguez A, Andrade CA, Berrios RV, Canedo-Marroquín G, Covián C, Moreno-Tapia D, Saavedra F, Vallejos OP, Donato P, Espinoza P, Fuentes D, González M, Guzmán P, Muñoz-Venturelli P, Pérez CM, Potin M, Rojas Á, Fasce R, Fernández J, Mora J, Ramírez E, Gaete-Argel A, Oyarzún-Arrau A, Valiente-Echeverría F, Soto-Rifo R, Weiskopf D, Sette A, Zeng G, Meng W, González-Aramundiz JV, Kalergis AM, (2021).

15. Extending the endocrine hypertension spectrum: novel nonclassic apparent mineralocorticoid excess. Carvajal CA, Tapia-Castillo A, Fardella CE, (2021). Endocrinology. doi: 10.1007/s12020-021-02783-1.

16. Novel metabolomic profile of subjects with non-classic apparent mineralocorticoid excess., Scientific Reports. 10.1038/s41598-021-96628-6. Tapia-Castillo A, Carvajal CA, López-Cortés X, Vecchiola A, Fardella CE, (2021).

17. Plasminogen activator inhibitor-1 and Adiponectin are associated with metabolic syndrome components. Vecchiola A, García K, González-Gómez LM, Tapia-Castillo A, Artigas R, Baudrand R, Kalergis AM, Carvajal CA, Fardella CE, (2021). American Journal of Hypertension. doi: 10.1093/ajh/hpab138.

18. Lung pathology due to hRSV infection impairs blood-brain barrier permeability enabling astrocyte infection and a long-lasting inflammation in the CNS. Bohmwald K, Soto JA, Andrade-Parra C, Fernández-Fierro A, Espinoza JA, Ríos M, Eugenin EA, González PA, Opazo MC, Riedel CA, Kalergis AM, (2021). Brain Behav Immun. doi: 10.1016/j.bbi.2020.09.021.

19. Respiratory viral infections during pregnancy: effects of SARS-CoV-2 and other related viruses over the offspring. Riedel C, Rivera JC, Canedo-Marroquín G, Kalergis AM, Opazo MC, (2021). Cambridge University Press. doi:10.1017/S2040174420001373.

20. Single Nucleotide Polymorphisms in Apolipoprotein B, Apolipoprotein E, and Methylenetetrahydrofolate Reductase Are Associated With Serum Lipid Levels in Northern Chilean Subjects. A Pilot Study., Front Genet. 10.3389/fgene.2021.640956. Gálvez AS, Ramírez H, Placencia P, Rojas C, Urzúa X, Kalergis AM, Salazar LA, Escobar-Vera J, (2021).

21. Modulation of Adaptive Immunity and Viral Infections by Ion Channels. Modulation of Adaptive Immunity and Viral Infections by Ion Channels., Front Physiol. 10.3389/fphys.2021.736681. Bohmwald K, Gálvez NMS, Andrade CA, Mora VP, Muñoz JT, González PA, Riedel CA, Kalergis AM, (2021).

22. Allergens of the urushiol family promote mitochondrial dysfunction by inhibiting the electron transport at the level of cytochromes b and chemically modify cytochrome c 1. Pacheco R, Quezada SA, Kalergis AM, Becker MI, Ferreira J, De Ioannes AE, (2021). Biol Res. doi: 10.1186/s40659-021-00357-z.

23. The double-stranded RNA-binding protein, Staufen1, is an IRES-transacting factor regulating HIV-1 cap-independent translation initiation., Nucleic Acid Research. 10.1093/nar/gkab1188. Ramos H., Monette A. ,Niu M., Barrera A, López-Ulloa B, Fuentes Y., Guizar P., Pino K., DesGroseiller, L., Mouland A.J., López-Lastra M., (2021).

24. New Insights on the Early Interaction Between Typhoid and Non-typhoid Salmonella Serovars and the Host Cells., Frontiers in Microbiology. 10.3389/fmicb.2021.647044. Schultz BM, Melo-Gonzalez F, Salazar GA, Porto BN, Riedel CA, Kalergis AM, Bueno SM., (2021).

25. Immune Profile and Clinical Outcome of Breakthrough Cases After Vaccination With an Inactivated SARS-CoV-2 Vaccine., Frontiers in Immunology. 10.3389/fimmu.2021.742914. Duarte LF, Gálvez NMS, Iturriaga C, Melo-González F, Soto JA, Schultz BM, Urzúa M, González LA, Vázquez Y, Ríos M, Berríos-Rojas RV, Rivera-Pérez D, Moreno-Tapia D, Pacheco GA, Vallejos OP, Hoppe-Elsholz G, Navarrete MS, Rojas Á, Fasce RA, Fernández J, Mora J, Ramírez E, Zeng G, Meng W, González-Aramundiz JV, González PA, Abarca K, Bueno SM and Kalergis AM, (2021).

26. Effective Treatment against ESBL-Producing Klebsiella pneumoniae through Synergism of the Photodynamic Activity of Re (I) Compounds with Beta-Lactams., Pharmaceutics. 10.3390/pharmaceutics13111889. González IA, Palavecino A, Núñez C, Dreyse P, Melo-González F, Bueno SM, Palavecino CE, (2021).

27. Activation of regulator ArcA in the presence of hypochlorite in Salmonella enterica serovar Typhimurium., Biochimie. 10.1016/j.biochi.2020.11.009. Cabezas CE, Laulié AM, Briones AC, Pardo-Esté C, Lorca DE, Cofré AA, Morales EH, Mora AY, Krüger GI, Bueno SM, Hidalgo AA, Saavedra CP, (2021).

28. Type I Natural Killer T Cells as Key Regulators of the Immune Response to Infectious Diseases., Clinical Microbiology Reviews. 10.1128/CMR.00232-20. Gálvez NMS, Bohmwald K, Pacheco GA, Andrade CA, Carreño LJ, Kalergis AM., (2021).

29. Induction of Protective Immunity by a Single Low Dose of a Master Cell Bank cGMP-rBCG-P Vaccine Against the Human Metapneumovirus in Mice. Soto JA, Gálvez NMS, Pacheco GA, Canedo-Marroquín G, Bueno SM, Kalergis AM, (2021). Front Cell Infect Microbiol. DOI: 10.3389/fcimb.2021.662714.

30. Molecular and Cellular Mechanisms Modulating Trained Immunity by Various Cell Types in Response to Pathogen Encounter. Front Immunol. 10.3389/fimmu.2021.745332. Acevedo OA, Berrios RV, Rodríguez-Guilarte L, Lillo-Dapremont B, Kalergis AM, (2021).

31. Contribution of Dysregulated DNA Methylation to Autoimmunity. Funes SC, Fernández-Fierro A, Rebolledo-Zelada D, Mackern-Oberti JP, Kalergis AM, (2021). Int J Mol Sci. doi: 10.3390/ijms222111892.

32. The Causes and Long-Term Consequences of Viral Encephalitis. Bohmwald K, Andrade CA, Gálvez NMS, Mora VP, Muñoz JT, Kalergis AM, (2021). Front Cell Neurosci. doi: 10.3389/fncel.2021.755875.

33. Host Components That Modulate the Disease Caused by hMPV. Gálvez NMS, Andrade CA, Pacheco GA, Soto JA, Stranger V, Rivera T, Vásquez AE, Kalergis AM, (2021). Viruses. doi: 10.3390/v13030519.

34. A Recombinant BCG Vaccine Is Safe and Immunogenic in Neonatal Calves and Reduces the Clinical Disease Caused by the Respiratory Syncytial Virus. Front Immunol. 10.3389/fimmu.2021.664212. Díaz FE, Guerra-Maupome M, McDonald PO, Rivera-Pérez D, Kalergis AM, McGill JL, (2021).

35. Bacterial and Viral Coinfections with the Human Respiratory Syncytial Virus. Pacheco GA, Gálvez NMS, Soto JA, Andrade CA, Kalergis AM, (2021). Microorganisms. doi: 10.3390/microorganisms9061293.

36. LDL particle size and antioxidant HDL function improve after sustained virological response in patients with chronic HCV. Annals of Hepatology. 10.1016/j.aohep.2021.100555. Vargas JI, Rivera K, Arrese M, Benitez C, Barrera F, Hugo M, Arab JP, Pino K, Barrera A, Lopez-Lastra M, Rigotti A, Soza A., (2021).

37. The viral nucleocapsid protein and the human RNA-binding protein Mex3A promote translation of the Andes orthohantavirus small mRNA. PLOS Pathogen. 10.1371/journal.ppat.1009931. Vera-Otarola J, Castillo-Vargas E, Angulo J, Barriga FM, Batlle E, Lopez-Lastra M., (2021).

38. The internal ribosome entry site of the Dengue virus mRNA is active when cap-dependent translation initiation is inhibited. Journal of Virology, 10.1128/JVI.01998-20. Fernández-García L, Angulo J, Ramos H, Barrera A, Pino K, Vera-Otarola J, López-Lastra M., (2021).

39. Dysregulated Immune Responses in COVID-19 Patients Correlating With Disease Severity and Invasive Oxygen Requirements. Frontiers Immunology. 10.3389/fimmu.2021.769059. Garcia- Gonzalez, P., Tempio, F., Fuentes, C., Merino C., Vargas, L., Simon, V., Ramirez-Pereira M., Rojas V., Tobar., E., Landskron, G., Araya JP., Navarrete, M., Bastias C., Tordecilla R., Varas, M., Maturan, P., Marcoleta A., Allende M.L., Naves, R., Hermoso, M., Salazar-Onfray, F., Lopez M.N., Bono M.R., and Osorio, F. , (2021).

40. Invitro Phenotyope induction of Circulating Monocytes CD16 and CD163 Analysis., Journal of inflamation research. 10.2147/JIR.S292513. Karsulovic, C., Tempio F., López M.N., Guerrero, J., and Goecke, A, (2021).

41. The Role of CXCL10 and IL-18 as Markers of Repigmentation Response in Nonsegmental Vitiligo Treated with Narrowband UVB Phototherapy: A Prospective Cohort Study., Journal of investigative Dermatology. 10.1016/j.jid.2020.12.021. Hojman, L., Cabrera, R., Karsulovic, C., Tempio, F., Perez, C., López, M.N., (2021).

42. Aminoguanidine Prevents the Oxidative Stress, Inhibiting Elements of Inflammation, Endothelial Activation, Mesenchymal Markers, and Confers a Renoprotective Effect in Renal Ischemia and Reperfusion Injury. Antioxidants. 10.3390/antiox10111724. Pasten C, Lozano M, Rocco J, Carrión F, Alvarado C, Liberona J, Michea L, Irarrázabal CE., (2021).

43. Effect of Helicobacter pylori eradication therapy on clinical and laboratory biomarkers associated with gastric damage in healthy school-aged children: A randomized non-blinded trial. Lucero Y, Lagomarcino AJ, Torres JP, Roessler P, Mamani N, George SA, Huerta N, González M, O’Ryan G M., (2021). Helicobacter. doi: 10.1111/hel.12853.

44. Safeguarding vaccine production and supply strategies for polio eradication endgame. Bandyopadhyay AS, O’Ryan M., (2021). Lancet Reg Health West Pac. doi: 10.1016/j.lanwpc.2021.100159.

45. Helicobacter pylori, clinical, laboratory, and noninvasive biomarkers suggestive of gastric damage in healthy school-aged children: A case-control study. Lucero Y, Lagomarcino AJ, Torres JP, Roessler P, Mamani N, George S, Huerta N, Gonzalez M, O’Ryan M., (2021). Int J Infect Dis. doi: 10.1016/j.ijid.2020.11.202.

46. Attended Automated Office Blood Pressure Measurement Versus Ambulatory Blood Pressure Monitoring in a Primary Healthcare Setting in Chile. South Medical Journal. 10.14423/SMJ.0000000000001206. Michea L , Toro L, Alban N , Contreras D , Morgado P, Paccot M, Escobar MC , Lorca E, (2021).

47. Glutathione S-Transferase and Clusterin, New Players in the Ischemic Preconditioning Renal Protection in a Murine Model of Ischemia and Reperfusion. Cellular Physiology & Biochemistry. 10.33594/000000442. Pasten C, Herrera-Luna Y, Lozano M, Rocco J, Alvarado C, Liberona J, Michea L, Irarrázabal CE, (2021).

48. Dynamic IgG seropositivity after rollout of CoronaVac and BNT162b2 COVID-19 vaccines in Chile: a sentinel surveillance study. Sauré D, O’Ryan M, Torres JP, Zuniga M, Santelices E, Basso LJ, (2021). Lancet Infect Dis. doi: 10.1016/S1473-3099(21)00479-5.

49. The burden of norovirus disease in children: a multi-country study in Chile, Brazil, Thailand and the Philippines. Safadi MA, Riera-Montes M, Bravo L, Tangsathapornpong A, Lagos R, Thisyakorn U, Linhares AC, Capeding R, Prommalikit O, Verstraeten T, O’Ryan M. , (2021). Int J Infect Dis. doi: 10.1016/j.ijid.2021.06.037.

50. Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Prevalence in Blood in a Large School Community Subject to a Coronavirus Disease 2019 Outbreak: A Cross-sectional Study. Torres JP, Piñera C, De La Maza V, Lagomarcino AJ, Simian D, Torres B, Urquidi C, Valenzuela MT, O’Ryan M., (2021). Clin Infect Dis. doi: 10.1093/cid/ciaa955.

51. Norovirus: Facts and Reflections from Past, Present, and Future. Lucero, Y.; Matson, D.O.; Ashkenazi, S.; George, S.; O’Ryan, M. , (2021). Viruses. https://doi.org/ 10.3390/v13122399.

52. The Role of Serology Testing in the Context of Immunization Policies for COVID-19 in Latin American Countries. dos Santos Ferreira, C.E.; Gómez-Dantés, H.; Junqueira Bellei, N.C.; López, E.; Nogales Crespo, K.A.; O’Ryan, M.; Villegas, J. , (2021). Viruses. https://doi.org/ 10.3390/v13122391.

53. Cancer research in Latin America, 2014-2019, and its disease burden, Journal of Scientometric Res. 10.5530/jscires.10.1s.19. Lewison G., Owen GI., Gomez H., Cazap E., Murillo R., Saldaña KU., Dreyer M., Tsunoda A., Jimenez de la Jara J., (2021).

54. Mechanobiology of autophagy: The unexplored side of cancer., Frontiers in Oncology. 10.3389/fonc.2021.632956. Hérnandez-Cáceres MP., Muñoz L., Pradenas JM., Pena F., Lagos P., Aceiton P., Owen GI., Morselli E., Criollo A., Ravasio A., Bertocchi C., (2021).

55. Thyroid Gene Mutations in Pregnant and Breastfeeding Women Diagnosed With Transient Congenital Hypothyroidism: Implications for the Offspring’s Health., Frontiers in endocrinology. 10.3389/fendo.2021.679002. Opazo MC, Rivera JC, Gonzalez PA, Bueno SM, Kalergis AM, Riedel CA, (2021).

56. C-type lectin receptors MR and DC-SIGN are involved in recognition of hemocyanins, shaping their immunostimulatory effects on human dendritic cells. Villar J, Salazar ML, Jiménez JM, Campo MD, Manubens A, Gleisner MA, Ávalos I, Salazar-Onfray F, Salazar F, Mitchell DA, Alshahrani MY, Martínez-Pomares L, Becker MI, (2021). European Journal of Immunology. DOI: 10.1002/eji.202149225.

57. A case-control study of a combination of single nucleotide polymorphism and clinical parameters to predict clinically relevant toxicity associated with fluoropyrimidine and platinum-based chemotherapy in gastric cancer., BMC Cancer. 10.1186/s12885-021-08745-0. Cordova-Delgado M., Nravo ML., Cumsille E., Hill CN., Muñoz-Medel M., Pinto MP., Retamal IN., Lavanderos MA., Miquel JF., Rodriguez-Fernandez M., Liao Y., Li Z., Corvalán AH., Armisén R., Garrido M., Quiñones LA., Owen GI., (2021).

58. CD73 Ectonucleotidase Restrains CD8+ T Cell Metabolic Fitness and Anti-tumoral Activity, Frontiers in Cell and Developmental Biology. 10.3389/fcell.2021.638037. Briceño P, Rivas-Yañez E, Rosemblatt MV, Parra-Tello B, Farías P, Vargas L, Simon V, Cárdenas C, Lladser A, Salazar-Onfray F, Elorza AA, Rosemblatt M, Bono MR, Sauma D., (2021).

59. The Evaluation of 17 Gastrointestinal Tumor Markers Reveals Prognosis Value for MUC6, CK17, and CD10 in Gallbladder-Cancer Patients. Carrasco C, Tittarelli A, Paillaleve N, Pozo MD, Rojas-Sepúlveda D, Barría O, Fluxá P, Hott M, Martin C, Quezada C, Salazar-Onfray F., (2021). Diagnostics (Basel). doi: 10.3390/diagnostics11020153.

60. Immunosuppressive Mechanisms of Regulatory B Cells, Frontiers in Immunology. 16643224, 10.3389/fimmu.2021.611795. Catalán D, Mancilla MA, Ferrier A, Soto L, Oleinika K, Aguillón JC, Aravena O. , (2021).

61. Comparing Approaches to Normalize, Quantify, and Characterize Urinary Extracellular Vesicles. J Am Soc Nephrol. 1555-9041, 10.1681 / ASN.2020081142. Charles J. Blijdorp , Omar A. Z. Tutakhel , Thomas A. Hartjes, Thierry P. P. van den Bosch,Martijn H. van Heugten, Juan Pablo Rigalli, Rob Willemsen,Usha M. Musterd-Bhaggoe, Eric R. Barros, Roger Carles-Fontana,Cristian A. Carvajal , Onno J. Arntz, Fons A. J. van de Loo, Guido Jenster,Marian C. Clahsen-van Groningen, Cathy A. Cuevas, David Severs, Robert A. Fenton,Martin E. van Royen , Joost G. J. Hoenderop , René J. M. Bindels , andEwout J. Hoorn «, (2021).

62. Extracellular vesicles regulate purinergic signaling and epithelial sodium channel expression in renal collecting duct cells. The Faseb Journal. 0892-6638, 10.1096/fj.202002559R. Eric R. Barros Lamus, Valentina Carotti,Christine R. S. de Vries, Femke Witsel,Onno J. Arntz, Fons A. J. van de Loo, Cristian A. Carvajal, René J. M. Bindels,Joost G. J. Hoendero, Juan P. Rigalli, (2021).

63. Proteomic Profile of Urinary Extracellular Vesicles Identifies AGP1 as a Potential Biomarker of Primary Aldosteronism. Endocrinology. 1365-2265, 10.1210/endocr/bqab032. Barros ER, Rigalli JP, Tapia-Castillo A, Vecchiola A, Young MJ, Hoenderop JGJ, Bindels RJM, Fardella CE, Carvajal CA, (2021).

64. Serum alpha-1-acid glycoprotein-1 and urinary extracellular vesicle miR-21-5p as potential biomarkers of primary aldosteronism. Frontiers in Immunology. 1664-3224, 10.3389/fimmu.2021.768734. Carvajal CA. Tapia-Castillo A, Perez J, Fardella CE, (2021).

65. Primary aldosteronism, aldosterone and extracellular vesicles. Endocrinology. 1365-2265, doi.org/10.1210/endocr/bqab240. Carvajal CA. Tapia-Castillo A, Perez J, Fardella CE, (2021).

66. Aldosterone and renin concentration were abnormally elevated in a cohort of normotensive pregnant women. Endocrinology. 1365-2265, 10.1007/s12020-021-02938-0. Pasten V, Tapia-Castillo A, Fardella CE, Leiva A, Carvajal CA, (2021).

67. Respiratory viral infections during pregnancy: effects of SARS-CoV-2 and other related viruses over the offspring. International Society for Developmental Origins of Health and Disease. 2040-1744, https://doi.org/10.1017/S2040174420001373. Riedel C, Rivera JC, Canedo-Marroquín G, Kalergis AM, Opazo MC, (2021).

68. Role of inflammation in hypertension. Revista Medica de Chile, 10.4067/s0034-98872021000200255. Prat H, Araos P, Michea L., (2021).

69. Herpes Simplex Viruses Type 1 and Type 2 Infection and Immunity. Antonia Reyes, Mónica A. Farías, Nicolás Corrales, Eduardo Tognarelli, Pablo A.González, (2021). Reference Module in Biomedical Sciences. https://doi.org/10.1016/B978-0-12-818731-9.00062-8.

70. Interim Report: safety and immunogenicity of an inactivated vaccine 2 against SARS-CoV2 in healthy Chilean adults in a phase 3 clinical trial. MedRxiv, 10.1101/2021.03.31.21254494. Bueno SM*, Abarca K, González PA, Gálvez NMS, Soto JA, Duarte LF, Schultz BM, Pacheco GA, González LA, Vázquez Y, Ríos M, Melo-González F, Rivera-Pérez D, Iturriaga C, Urzúa M, Dominguez A, Andrade CA, Berrios RV, Canedo-Marroquín G, Covián C, Moreno-Tapia D, Saavedra F, Vallejos OP, Donato P, Espinoza P, Fuentes D, González M, Guzmán P, Muñoz-Venturelli P, Pérez CM, Potin M, Rojas A, Fasce R, Fernández J, Mora J, Ramírez E, Gaete-Argel A, Oyarzún-Arrau A, Valiente-Echeverría F, Soto-Rifo R, Weiskopf D, Sette A, Zeng G, Meng W, González-Aramundiz JV, Kalergis AM*, (2021).

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72. Lung pathology due to hRSV infection impairs blood–brain barrier permeability enabling astrocyte infection and a long-lasting inflammation in the CNS Karen Bohmwald, Jorge A. Soto, Catalina Andrade-Parra, Ayleen Fernández-Fierro, Janyra A. Espinozaa, Mariana Ríos, Eliseo A. Eugenin, Pablo A. González, María Cecilia Opazo, Claudia A. Riedel, Alexis M. Kalergis. Brain, Behaviour and Immunity https://doi.org/10.1016/j.bbi.2020.09.021.

1. The Internal Ribosome Entry Site of Dengue Virus mRNA Is Active When Cap-Dependent Translation Initiation Is Inhibited. Leandro Fernández-García, Jenniffer Angulo, Hade Ramos, Aldo Barrera, Karla Pino, Jorge Vera-Otarola,. Marcelo López-Lastraa. J Virol 95:e01998-20. https://doi.org/10.1128/JVI.01998-20.

2. Lung pathology due to hRSV infection impairs blood–brain barrier permeability enabling astrocyte infection and a long-lasting inflammation in the CNS Karen Bohmwald, Jorge A. Soto, Catalina Andrade-Parra, Ayleen Fernández-Fierro, Janyra A. Espinozaa, Mariana Ríos, Eliseo A. Eugenin, Pablo A. González, María Cecilia Opazo, Claudia A. Riedel, Alexis M. Kalergis. Brain, Behaviour and Immunity https://doi.org/10.1016/j.bbi.2020.09.021.

3. ICD-10 coded hospitalizations due to drug hypersensitivity: A nationwide study from Chile Juan J. Escobar, BS, Raquel Aguilera-Insunz, MD, MMS, Arturo Borzutzky, MD, and Rodrigo Hoyos-Bachiloglu, MD, MMSc. The Journal of Allergy and Clinical Immunology: In Practice2020 Mar;8(3):1156-1158.e2. doi: 10.1016/j.jaip.2019.10.012. Epub 2019 Oct 31.

4. Repertoire and Diversity of Toxin–Antitoxin Systems of Crohn’s Disease-Associated Adherent-Invasive Escherichia coli. New Insight of This Emergent E. coli Pathotype. Paula Bustamante and Roberto Vidal. Front. Microbiol. 11:807. doi: 10.3389/fmicb.2020.00807.

5. Human Norovirus Proteins: Implications in the Replicative Cycle, Pathogenesis, and the Host Immune Response., Frontiers in Immunology. 1664-3224, 10.3389/fimmu.2020.00961 Campillay-Véliz CP, Carvajal JJ, Avellaneda AM, Escobar D, Covián C, Kalergis AM, Lay MK, (2020).

6. Current antivirals and novel botanical molecules interfering with herpes simplex virus infection., Fontiers in Microbiology. 1664-302X, DOI: 10.3389/fmicb.2020.00139. Alvarez DM, Castillo E, Duarte LF, Arriagada J, Corrales N, Farías MA, Henríquez A, Agurto-Muñoz A, González PA, (2020).

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1. Antimicrobial properties of a novel copper-based composite coating with potential for use in healthcare facilities. David A Montero, Carolina Arellano; Mirka Pardo; Rosa Vera; Ricardo Gálvez; Marcela Cifuentes; María A Berasain; Marisol Gomez; Claudio Ramírez; Roberto Vidal. Antimicrobial Resistance & Infection Control. DOI: 10.1186/s13756-018-0456-4. Related research line: New developments of copper surfaces in health and food production institutions. Publication date: 05-01-19.

2. Identification and detection of iha subtypes in LEE-negative Shigatoxin-producing Escherichia coli (STEC) strains isolated from humans, cattle and food. Rocío Colello, Alejandra Krüger, María Victoria Velez, Felipe Del Canto, Analía Inés Etcheverría, Roberto Vidal, Nora Lía Padola Heliyon. DOI: 10.1016/j.heliyon.2019.e03015.Related research line: Pathogenic E. coli. Publication date: 06-12-19.

3. Pertussis Prevention: Reasons for Resurgence, and Differences in the Current Acellular Pertussis Vaccines. Esposito, Susanna; Stefanelli, Paola; Fry, Norman K.; Fedele, Giorgio; He, Qiushui; Paterson, Pauline; Tan, Tina; Knuf, Markus; Rodrigo, Carlos; Olivier, Catherine Weil; Flanagan, Katie L.; Hung, Ivan; Lutsar, Iria; Edwards, Kathryn; O’Ryan, Miguel; Principi, Nicola. Frontiers in Immunology. DOI: 10.3389/fimmu.2019.01344. Related research line: Rotavirus and other enteric virus infections and vaccine development. Publication date: 03-07-19.

4. Genome and Functional Characterization of Colonization Factor Antigen I- and CS6-Encoding Heat-Stable Enterotoxin-Only Enterotoxigenic Escherichia coli Reveals Lineage and Geographic Variation. Tracy H. Hazen, Sushma Nagaraj, Sunil Sen, Jasnehta Permala-Booth, Felipe Del Canto, Roberto Vidal, Eileen M. Barry, Jacob P. Bitoun, Wilbur H. Chen, Sharon M. Tennant, David A. Rasko mSystems. DOI: 10.1128/mSystems.00329-18. Related research line: Pathogenic E. coli. Publication date: 15-01-19.

5. Cumulative acquisition of pathogenicity islands has shaped virulence potential and contributed to the emergence of LEE-negative Shiga toxin-producing Escherichia coli strains. David Arturo Montero, Felipe Del Canto, Juliana Velasco, Rocío Colello, Nora Lia Padola, Juan Carlos Salazar, Carla San Martin, Angel Oñate, Jorge Blanco, David A. Rasko, Carmen Contreras, Jose Luis Puente, Flemming Scheutz, Eelco Franz & Roberto M. Vidal Emerging Microbes & Infections. DOI: 10.1080/22221751.2019.1595985. Related research line: Pathogenic E. coli. Publication date: 29-03-19.

6. New insights for vaccine development against Clostridium difficile infections. Pizarro-Guajardo M, Chamorro-Veloso N, Vidal RM, Paredes-Sabja D. Anaerobe DOI: 10.1016/j.anaerobe.2019.04.009. Related research line: Chimeric vaccine design for STEC. Publication date: 26-04-19.

7. Ten years of molecular epidemiology surveillance of Listeria monocytogenes in Chile. Paduro C, Montero DA, Chamorro N, Carreño LJ, Vidal M, Vidal R Food Microbiology. DOI: 10.1016/j.fm.2019.103280. Related research line: Other Food pathogens like Listeria monocytogenes. Publication date: 26-07-19.

8. Comparative genomic analysis and molecular examination of the diversity of enterotoxigenic Escherichia coli isolates from Chile. Rasko DA, Del Canto F, Luo Q, Fleckenstein JM, Vidal R, Hazen TH PLoS Neglected Tropical Disease. DOI: 10.1371/journal.pntd.0007828. Related research line: Pathogenic E. coli. Publication date: 20-11-19.

9. Cytokines in the Respiratory Airway as Biomarkers of Severity and Prognosis for Respiratory Syncytial Virus Infection: An Update. Vázquez Y, González L, Noguera L, González PA, Riedel CA, Bertrand P, Bueno SM. Frontiers in Immunology. DOI: 10.3389/fimmu.2019.01154. Related research line: Identification of antigens of human respiratory pathogens and human proinflammatory cytokines for the diagnosis of severe respiratory diseases. Publication date: 04-06-19.

10. Interleukin-10 Produced by Myeloid-Derived Suppressor Cells Provides Protection to Carbapenem-Resistant Klebsiella pneumoniae Sequence Type 258 by Enhancing Its Clearance in the Airways. Peñaloza HF, Noguera LP, Ahn D, Vallejos OP, Castellanos RM, Vazquez Y, Salazar-Echegarai FJ, González L, Suazo I, Pardo-Roa C, Salazar GA, Prince A, Bueno SM. Infection and Immunity. DOI: 10.1128/IAI.00665-18. Related research line: Role of pro and anti-inflammatory cytokines in the susceptibility of the host to infectious diseases. Publication date: 23-04-19.

11. Dendritic Cells Loaded with Heat Shock-Conditioned Ovarian Epithelial Carcinoma Cell Lysates Elicit T Cell-Dependent Antitumor Immune Responses In Vitro. Flores I, Hevia D, Tittarelli A, Soto D, Rojas-Sepúlveda D, Pereda C, Falcón-Beas C, Gatica J, Falcón-Beas F, González FE,Galindo Mario, Salazar-Onfray F, López MN Journal Immunological Research. DOI: 10.1155/2019/9631515. Related research line: Immunology and Cancer. Publication date: 16-10-19.

12. «Cx43-Gap Junctions Accumulate at the Cytotoxic Immunological Synapse Enabling Cytotoxic T Lymphocyte Melanoma Cell Killing». Hofmann F, Navarrete M, Álvarez J, Guerrero I, Gleisner MA, Tittarelli A, Salazar-Onfray F. International Journal of Molecular Medicine. DOI: 10.3390/ijms20184509. Related research line: Connexins and Gap Junctions interaction between Immune cells and tumors. Publication date: 12-09-19.

13. Association Between Plasma Antibody Responses and Risk for Cryptococcus-Associated Immune Reconstitution Inflammatory Syndrome. Yoon HA, Nakouzi A, Chang CC, Kuniholm MH, Carreño LJ, Wang T, Ndung’u T, Lewin SR, French MA, Pirofski L Journal of Infectious Disesases. DOI: 10.1093/infdis/jiy447. Related research line: Improving viral immunity by targeting Natural Killer T cells. Publication date: 09-01-19.

14. l-NIL prevents the ischemia and reperfusion injury involving TLR-4, GST, clusterin, and NFAT-5 in mice. Consuelo Pasten, Cristóbal Alvarado, Jocelyn Rocco, Luis Contreras, Paula Aracena, Jéssica Liberona, Cristian Suazo, Luis Michea, and Carlos E. Irarrázabal American Journal of Physiology – Renal Physiology. DOI: 10.1152/ajprenal.00398.2018. Related research line: Role of dietary chloride as accompanying ion of sodium in Angiotensin II hypertension. Publication date: 30-04-19.

15. The cancer-related transcription factor RUNX2 modulates expression and secretion of the matricelllar protein. Villanueva F, Araya H, Briceño P, Varela N, Stevenson A, Jerez S, Tempio F, Chnaiderman J, Perez C, Villarroel M, Concha E, Khani F, Thaler R, Salazar-Onfray F, Stein GS, van Wijnen AJ, Galindo M. Journal Cell Physiology. DOI: 10.1002/jcp.28046. Related research line: Design of improved vaccines against cancer. Publication date: 31-08-19.

16. Is there an association between indoor allergens and the severity of atopic dermatitis? Cid BJ, Perez-Mateluna G, Iturriaga C, Zambrano MJ, Vives MI, Valenzuela PM, Borzutzky A. International Journal of Dermatology. DOI: 10.1111/ijd.14281. Related research line: Pathogenesis of atopic dermatitis. Publication date: 30-04-19.

17. Vitamin D modulates the allergic phenotype of dendritic cells in children with atopic dermatitis. Cristi F, Pérez-Mateluna G, Vera-Kellet C, Silva-Valenzuela S, Iturriaga C, Hoyos-Bachiloglu R, Navarrete-Dechent C, Cifuentes L, Camargo CA, Kalergis A, Borzutzky A. Experimental Dermatology. DOI: 10.1111/exd.13873. Related research line: Pathogenesis of atopic dermatitis. Publication date: 31-03-19.

18. Glucocorticoids Decrease Longitudinal Bone Growth in Pediatric Kidney Transplant Recipients by Stimulating the FGF23/FGFR3 Signaling Pathway. Ángela Delucchi, Luis Toro, Rodrigo Alzamora, Victor Barrientos, Magdalena González, Rodrigo Andaur, Pablo León, Francisco Villanueva, Mario Galindo, Facundo Las Heras, Martín Montecino, Daniel Moena, Andrea Lazcano, Viola Pinto, Paulina Salas, María Loreto Reyes, Verónica Mericq, Luis Michea The American Society for Bone and Mineral Research. DOI: 10.1002/jbmr.3761. Related research line: To evaluate if FGF23 is implicated and/or a useful biomarker of Acute kidney Injury (AKI). Publication date: 31-10-19.

19. Dendritic cells are crucial for cardiovascular remodeling and modulate neutrophil gelatinase-associated lipocalin expression upon mineralocorticoid receptor activation. Patricio Araos, Carolina Prado, Mauricio Lozano, Stefanny Figueroa, Alexandra Espinoza, Thorsten Berger, Tak Mak, Frédéric Jaisser, Rodrigo Pacheco, Luis Michea, Cristián Amador; Journal of Hypertension. DOI: 10.1097/HJH.0000000000002067. Related research line: Role of dietary chloride as accompanying ion of sodium in Angiotensin II hypertension. Publication date: 31-07-19.

20. TRPM4 channel is involved in regulating epithelial to mesenchymal transition, migration, and invasion of prostate cancer cell lines. Alfredo I. Sagredo, Eduardo A. Sagredo, Victor Pola, César Echeverría, Rodrigo Andaur, Luis Michea, Andrés Stutzin, Felipe Simon, Katherine Marcelain, Ricardo Armisén Journal of Cellular Physiology. DOI: 10.1002/jcp.27371. Related research line: Immunological aspects of Galbladder tumors. Publication date: 31-03-19.

21. Host Component Contributing to Respiratory Syncytial Virus Pathogenesis. Carvajal JJ, Avellaneda AM, Salazar-Ardiles CN, Maya JE, Kalergis AM, Lay MK Frontiers Immunology. DOI: 10.3389/fimmu.2019.02152. Related research line: Host factors on and viral induced disease outcome. Publication date: 12-09-19.

22. BCG-Induced Cross-Protection and Development of Trained Immunity: Implication for Vaccine Design. Covia´n C, Ferna´ndez-Fierro A, Retamal-Di´az A, Di´az FE, Vasquez AE, Lay MK, Riedel CA, Gonza´lez PA, Bueno SM and Kalergis AM Frontiers Immunology. DOI: 10.3389/fimmu.2019.02806. Related research line: Host factors on and viral induced disease outcome. Publication date: 29-11-19.

23. Correlation between female sex, IL28B genotype, and the clinical severity of bronchiolitis in pediatric patients. Astudillo P, Angulo J, Pino K, de Carvalho JB, de Morais GL, Perez S, de Vasconcelos ATR, Ferrés M, López-Lastra M. Pediatric Research. DOI: 10.1038/s41390-019-0623-1. Related research line: Host factors on and viral induced disease outcome. Publication date: 23-10-19.

24. A Single-Nucleotide Polymorphism of aVß3 Integrin Is Associated with the Andes Virus Infection Susceptibility. Martínez-Valdebenito C, Angulo J, Le Corre N, Marco C, Vial C, Miquel JF, Cerda J, Mertz G, Vial P, Lopez-Lastra M, Ferrés M. Viruses. DOI: 10.3390/v11020169. Related research line: Host factors on and viral induced disease outcome. Publication date: 20-02-19.

25. Severe Necrotic Reaction to 23-Valent Polysaccharide Pneumococcal Vaccine in a Patient With STAT3 Deficiency. Piñones M, Vizcaya C, Pérez-Mateluna G, Hoyos-Bachiloglu R, Borzutzky A. Journal Allergy Clinical Immunology: in Practice. DOI: 10.1016/j.jaip.2019.01.033. Related research line: Discovery and characterization of novel genetic etiologies of primary immunodeficiencies. Publication date: 31-05-19.

26. Helicobacter pylori pediatric infection changes FceRI expression in dendritic cells and Treg profile in vivo and in vitro. Leon MA, Palma C, Hernandez C, Sandoval M, Cofre C, Perez-Mateluna G, Borzutzky A, Harris PR, Serrano CA. Microbes and Infection. DOI: 10.1016/j.micinf.2019.05.001. Related research line: Discovery and characterization of novel genetic etiologies of primary immunodeficiencies. Publication date: 02-12-19.

27. Novel penguin Avian avulaviruses 17, 18 and 19 are widely distributed in the Antarctic Peninsula. Olivares F, Tapia R, Gálvez C, Meza F, Barriga GP, Borras-Chavez R, Mena-Vasquez J, Medina RA, Neira V. Transboundary and Emerging Diseases. DOI: 10.1111/tbed.13309. Related research line: Molecular Virology – Influenza. Publication date: 29-07-19.

28. Dexamethasone turns tumor antigen-presenting cells into tolerogenic dendritic cells with T cell inhibitory functions. Falcón-Beas C, Tittarelli A, Mora-Bau G, Tempio F, Pérez C, Hevia D, Behrens C, Flores I, Falcón-Beas F, Garrido P, Ascui G, Pereda C, González FE, Salazar-Onfray F, López MN Immunobiology. DOI: 10.1016/j.imbio.2019.05.011. Related research line: New antigens and vaccines against cancer. Publication date: 06-06-19.

29. Coagulation Factor Xa Promotes Solid Tumor Growth, Experimental Metastasis and Endothelial Cell Activation. Arce M, Pinto MP, Galleguillos M, Muñoz C, Lange S, Ramirez C, Erices R, Gonzalez P, Velasquez E, Tempio F, Lopez MN, Salazar-Onfray F, Cautivo K, Kalergis AM, Cruz S, Lladser Á, Lobos-González L, Valenzuela G, Olivares N, Sáez C, Koning T, Sánchez FA, Fuenzalida P, Godoy A, Contreras Orellana P, Leyton L, Lugano R, Dimberg A, Quest AFG, Owen GI. Cancers. DOI: 10.3390/cancers11081103. Related research line: New antigens and vaccines against cancer. Publication date: 02-08-19.

30. Inverse Relationship Between Alzheimer’s Disease and Cancer: How Immune Checkpoints Might Explain the Mechanisms Underlying Age-Related Diseases. Nicole K. Rogers, Cesar Romero, Carol D. SanMartín, Daniela P. Ponce, Felipe Salech, Mercedes N. López, Alejandra Gleisner, Fabián Tempio, María I. Behrens Journal of Alzheimer’s Diseases. DOI: 10.3233/JAD-190839. Related research line: Design of improved vaccines against cancer. Publication date: 09-12-19.

31. Primary Intestinal Lymphangiectasia (Waldmann’s disease) Borzutzky A, Espino A, Alberti G, Torres J, Harris PR. American Journal of Gastroenterology. DOI: 10.1038/s41395-018-0413-0. Related research line: Discovery and characterization of novel genetic etiologies of primary immunodeficiencies. Publication date: 28-02-19.

32. Disseminated Mycobacterial Disease in a Patient with 22q11.2 Deletion Syndrome: Case Report and Review of the Literature Hoyos-Bachiloglu R, Gallo S, Vizcaya C, Zuñiga P, Valbuena JR, Casanova JL, Bustamante J, Borzutzky A. Journal of Clinical Immunology. DOI: 10.1007/s10875-019-00678-5. Related research line: Discovery and characterization of novel genetic etiologies of primary immunodeficiencies. Publication date: 31-10-19.

33. Interleukin-8 Secreted by Glioblastoma Cells Induces Microvascular Hyperpermeability Through NO Signaling Involving S-Nitrosylation of VE-Cadherin and p120 in Endothelial Cells. Guequén A, Zamorano P, Córdova F, Koning T, Torres A, Ehrenfeld P, Boric MP, Salazar-Onfray F, Gavard J, Durán WN, Quezada C, Sarmiento J, Sánchez FA. Frontiers Physiology. DOI: 10.3389/fphys.2019.00988. eCollection 2019. Related research line: Design of improved vaccines against cancer. Publication date: 01-08-19.

34. Extracellular adenosine promotes cell migration/invasion of Glioblastoma Stem-like Cells through A3 Adenosine Receptor activation under hypoxia. Torres Á, Erices JI, Sanchez F, Ehrenfeld P, Turchi L, Virolle T, Uribe D, Niechi I, Spichiger C, Rocha JD, Ramirez M, Salazar-Onfray F, San Martín R, Quezada C. Cancer Letter. DOI: 10.1016/j.canlet.2019.01.004. Related research line: Design of improved vaccines against cancer. Publication date: 30-04-19.

35. IRE1a Activation in Bone Marrow-Derived Dendritic Cells Modulates Innate Recognition of Melanoma Cells and Favors CD8+ T Cell Priming. Medel B, Costoya C, Fernandez D, Pereda C, Lladser A, Sauma D, Pacheco R, Iwawaki T, Salazar-Onfray F, Osorio F. Frontiers in Immunology. DOI: 10.3389/fimmu.2018.03050. Related research line: New antigens and vaccines against cancer. Publication date: 31-01-19.

36. Chronic nonbacterial osteomyelitis in children: a multicenter case series. Concha S, Hernández-Ojeda A, Contreras O, Mendez C, Talesnik E, Borzutzky A. Rheumatology International. DOI: 10.1007/s00296-019-04400-x. Related research line: Discovery and characterization of novel genetic etiologies of primary immunodeficiencies. Publication date: 02-08-19.

37. Mandatory notifications of type 1 diabetes incident cases in Chilean children, 2006-2014: a population-based study Garfias CP, Borzutzky A, Ugarte MF, Garcia HJ, Phingsthorn M, Garcia HG. Pediatric Diabetes. DOI: 10.1111/pedi.12937. Related research line: Role of vitamin D in immune-mediated and other extraskeletal diseases in Chile. Publication date: 19-10-19.

38. Solar radiation, air pollution, and bronchiolitis hospitalizations in Chile: An ecological study. Terrazas C, Castro-Rodriguez JA, Camargo CA, Borzutzky A. Pediatric Pulmonology. DOI: 10.1002/ppul.24421. Related research line: Role of vitamin D in immune-mediated and other extraskeletal diseases in Chile. Publication date: 30-09-19.

39. ICD-10 coded hospitalizations due to drug hypersensitivity: A nationwide study from Chile. Escobar JJ, Aguilera-Insunza R, Borzutzky A, Hoyos-Bachiloglu R. Journal Allergy Clinical Immunology: in Practice. DOI: 10.1016/j.jaip.2019.10.012. Related research line: Early origins of allergy and asthma. Publication date: 31-10-19.

40. Mucosal Exposure to Cigarette Components Induces Intestinal Inflammation and Alters Antimicrobial Response in Mice. Berkowitz L, Pardo-Roa C, Salazar GA, Salazar-Echegarai F, Miranda JP, Ramírez G, Chávez JL, Kalergis AM, Bueno SM, Álvarez-Lobos M Frontiers in Immunology. DOI: 10.3389/fimmu.2019.02289. Related research line: IBD implications in Paneth Cells in patients that are smokers. Publication date: 25-09-19.

41. Conservation and global distribution of non-canonical antigens in Enterotoxigenic Escherichia coli. Kuhlmann FM, Martin J, Hazen TH, Vickers TJ, Pashos M, Okhuysen PC,Gómez-Duarte OG, Cebelinski E, Boxrud D, Del Canto F, Vidal R, Qadri F, Mitreva M, Rasko DA, Fleckenstein JM. PLoS Neglected Tropical Disease. DOI: 10.1371/journal.pntd.0007825. Related research line: Pathogenic E. coli. Publication date: 22-11-19.

42. New insights on the role of lipid metabolism in the metabolic reprogramming of macrophages. Ana Batista-Gonzalez, Roberto Mauricio Vidal, Alfredo Criollo and Leandro J Carreño Frontiers Immunology. DOI: 10.3389/fimmu.2019.02993. Related research line: Elaboration and characterization of anti-inflammatory lipsoomes to treat allergy. Publication date: 05-12-19.

43. Predominance of Rotavirus G8P[8] in a City in Chile, a Country Without Rotavirus Vaccination.Lucero, Yalda; O’Ryan, Miguel; Liparoti, Giulia; Huerta, Nicole; Mamani, Nora; Ramani, Sasirekha; Lagomarcino, Anne J.; Del Canto, Felipe; Quense, Jorge Journal of Pediatrics. DOI: 10.1016/j.jpeds.2018.08.037. Related research line: Rotavirus and other enteric virus infections and vaccine development. Publication date: 01-01-19.

44. Antibody persistence and booster response in adolescents and young adults 4 and 7.5 years after immunization with 4CMenB vaccine. Nolan, Terry; Elena Santolaya, Maria; de Looze, Ferdinandus; Marshall, Helen; Richmond, Peter; Henein, Sam; Rheault, Paul; Heaton, Ken; Perrett, Kirsten P.; Garfield, Hartley: Gupta, Anil; Ferguson, Murdo; D’Agostino, Diego; Toneatto, Daniela; O’Ryan, Miguel Vaccine. DOI: 10.1016/j.vaccine.2018.12.059. Related research line: Norovirus infection and vaccine development. Publication date: 21-02-19.

45. Chilean Registry for Neuroendocrine Tumors: A Latin American Perspective. Pinto MP, Muñoz Medel M, Carrillo D, Retamal IN, Bravo ML, Valenzuela Y, Nervi B, Sánchez C, Galindo H, Ibañez C, Peña J, Balmaceda C, Madrid J, Briones J, Torres J, Nilo F, Guarda FJ, Quintana JC, Orellana P, Mondaca S, Acevedo F, Vicentini D, Cordova-Delgado M, Owen GI, Garrido M Hormones & Cancer. DOI: 10.1007/s12672-018-0354-5. Related research line: Translational research in cancer. Publication date: 01-02-19.

46. Fact or Fiction, It Is Time for a Verdict on Vasculogenic Mimicry? Valdivia A, Mingo G, Aldana V, Pinto MP, Ramirez M, Retamal C, Gonzalez A, Nualart F, Corvalan AH, Owen GI Frontiers in Oncology. DOI: 10.3389/fonc.2019.00680. Related research line: Vasculogenic Mimicry in ovarian and gastrintestinal cancer. Publication date: 02-08-19.

47. High Proportion of Potential Candidates for Immunotherapy in a Chilean Cohort of Gastric Cancer Patients: Results of the FORCE1 Study. Cordova-Delgado M, Pinto MP, Retamal IN, Muñoz-Medel M, Bravo ML, Fernández MF, Cisternas B, Mondaca S, Sanchez C, Galindo H, Nervi B, Ibáñez C, Acevedo F, Madrid J, Peña J, Koch E, Maturana MJ, Romero D, de la Jara N, Torres J, Espinoza M, Balmaceda C, Liao Y, Li Z, Freire M, Gárate-Calderón V, Cáceres J, Sepúlveda-Hermosilla G, Lizana R, Ramos L, Artigas R, Norero E, Crovari F, Armisén R, Corvalán AH, Owen GI, Garrido M. Cancers. DOI: 10.3390/cancers11091275. Related research line: Immunology and Cancer. Publication date: 30-08-19.

48. Multi-objective optimization for personalized prediction of venous thromboembolism in ovarian cancer patients. Fresard ME, Erices R, Bravo ML, Cuello M, Owen GI, Ibanez C, Rodriguez-Fernandez M. IEEE Journal of Biomedical and Health Informatics. DOI: 10.1109/JBHI.2019.2943499. Related research line: Translational research in cancer. Publication date: 24-09-19.

49. Targeted deep sequencing from multiple sources demostrates increased NOTCH1 alterations in lung cancer patient plasma. Liao Y, Ma Z, Zhang Y, Li D, Lv D, Chen Z, Li P, Ai-Dherasi A, Zheng F, Tian J, Zou K, Wang Y, Wang D, Cordova M, Zhou H, Li X, Liu D, Yu R, Zhang X, Zhang J, Zhang X, Zhang X, Li Y, Shao Y, Song L, Liu R, Wang Y, Sufiyan S, Liu Q, Owen GI, Li Z, Chen J. Cancer Medicine. DOI: 10.1002/cam4.2458. Related research line: Translational research in cancer. Publication date: 01-08-19.

50. Regulation of Tolerogenic Features on Dexamethasone-Modulated MPLA-Activated Dendritic Cells by MYC. García-González PA, Maggi J, Schinnerling K, Sepúlveda-Gutiérrez A, Soto L, Neira O, Mehdi AM, Nel HJ, Pesce B, Aravena O, Molina MC, Catalán D, Thomas R, Verdugo RA, Aguillón JC. Frontiers in Immunology. DOI: 10.3389/fimmu.2019.01171. Related research line: Biology of dendritic cells and their therapeutic use in autoimmune diseases. Publication date: 28-05-19.

51. Clinical, Biochemical, and Genetic Characteristics of «Nonclassic» Apparent Mineralocorticoid Excess Syndrome. Tapia-Castillo A, Baudrand R, Vaidya A, Campino C, Allende F, Valdivia C, Vecchiola A, Lagos CF, Fuentes CA, Solari S, Martínez-Aguayo A, García H, Carvajal CA, Fardella CE. Journal of Clinical Endocrinology and Metabolism. DOI: 10.1210/jc.2018-01197.Related research line: Endocrine Hypertension. Publication date: 01-02-19.

52. The Aldosterone/Renin Ratio Predicts Cardiometabolic Disorders in Subjects Without Classic Primary Aldosteronism. Vecchiola A, Fuentes CA, Barros ER, Martínez-Aguayo A, García H, Allende F, Solari S, Olmos R, Carvajal C, Tapia-Castillo A, Campino C, Kalergis AM, Baudrand R, Fardella CE. American Journal Hypertension. DOI: 10.1093/ajh/hpz023. Related research line: Endocrine Hypertension. Publication date: 22-04-19.

53. Using plasma cell-free DNA to monitor the chemoradiotherapy course of cervical cancer. Tian J, Geng Y, Lv D, Li P, Cordova M, Liao Y, Tian X, Zhang X, Zhang Q, Zou K, Zhang Y, Zhang X, Li Y, Zhang J, Ma Z, Shao Y, Song L, Owen GI, Li T, Liu R, Liu Q, Zou L, Zhang Z, Li Z. International Journal of Cancer. DOI: 10.1002/ijc.32295. Related research line: Translational research in cancer. Publication date: 29-03-19.

54. The Reprimo gene family member, reprimo-like (rprml), is requerid for blood development in embryonic zebrafish. Stanic K, Reig G, Wichmann IA, Opazo JC, Owen GI, Corvalán AH, Concha ML, Amigo JD. Scientific Reports. DOI: 10.3390/cancers11060801. Related research line: Coagulation and Cancer. Publication date: 09-05-19.

55. Urinary sodium-to-potassium ratio and plasma renin and aldosterone concentrations in normotensive children: implications for the interpretation of results. Alejandro Martinez-Aguayo, Carmen Campino; Maria Rodriguez-Fernandez,Helena Poggi;Ivonne D’apremont; Rosario Moore;Hernan Garcia; Sandra Solari; Fidel Allende;S oledad Peredo;Claudia Trincado;Cristian Carvajal; Monica Arancibia; Jose Ossa; Sofia Sifaqui; Carlos Fardella; Rene Baudrand; Journal of Hypertension. DOI: 10.1097/HJH.0000000000002324. Related research line: Endocrine Hypertension. Publication date: 04-12-19.

56. Downregulation of exosomal miR 192 5p and miR 204 5p in subjects with nonclassic apparent mineralocorticoid excess Alejandra Tapia Castillo, Dominic Guanzon, Carlos Palma, Andrew Lai, Eric Barros, Fidel Allende, Andrea Vecchiola, Carlos E. Fardella, Carlos Salomón and Cristian A. Carvajal Journal of Translational Medicine. DOI: 10.1186/s12967 019 02143 8. Related research line: Endocrine Hypertension. Publication date: 27-11-19.

57. Circulating Endothelial Cells From Septic Shock Patients Convert to Fibroblasts Are Associated With the Resuscitation Fluid Dose and Are Biomarkers for Survival Prediction. Tapia P, Gatica S, Cortés-Rivera C, Otero C, Becerra A, Riedel CA, Cabello-Verrugio C, Kalergis AM, Simon F Critical Care Medicine. DOI: 10.1097/CCM.0000000000003778. Publication date: 01-07-19.

58. Mucin 5B, carbonic anhydrase 9 and claudin 18 are potential theranostic markers of gallbladder carcinoma. Espinoza JA, Riquelme I, Sagredo EA, Rosa L, García P, Bizama C, Apud-Bell M, Leal P, Weber H, Benavente F, Vargas S, Romero D, Kalergis AM, Roa JC. Histopathology. DOI: 10.1111/his.13797. Related research line: Immunological aspects of Galbladder tumors. Publication date: 28-01-19.

59. Immune checkpoints and the regulation of tolerogenicity in dendritic cells: Implications for autoimmunity and immunotherapy. Funes SC, Manrique de Lara A, Altamirano-Lagos MJ, Mackern-Oberti JP, Escobar-Vera J, Kalergis AM. Autoimmunity Reviews. DOI: 10.1016/j.autrev.2019.02.006. Related research line: Role of HO-1 in autoimmunity and tolerance. Publication date: 08-02-19.

60. Contribution of Fc? Receptor-Mediated Immunity to the Pathogenesis Caused by the Human Respiratory Syncytial Virus. Acevedo OA, Díaz FE, Beals TE, Benavente FM, Soto JA, Escobar-Vera J, González PA, Kalergis AM. Frontiers in Cellular and Infection Microbiology. DOI: 10.3389/fcimb.2019.00075. Related research line: Mechanisms of pathogenicity used by the human Respiratory Syncytial Virus to prevent T cell activation and cause Central Nervous System inflammation. Publication date: 29-03-19.

61. Copper deficiency-induced anemia is caused by a mitochondrial metabolic reprograming in erythropoietic cells. Jensen EL, Gonzalez-Ibanez AM, Mendoza P, Ruiz LM, Riedel CA, Simon F, Schuringa JJ, Elorza AA Metallomics. DOI: 10.1039/c8mt00224j. Related research line: Mitochondrial Function in Erythropoiesis. Publication date: 20-02-19.

62. Cellular immune response induced by surface immunogenic protein with AbISCO-100 adjuvant vaccination decreases group B Streptococcus vaginal colonization. Soto JA, Diaz-Dinamarca DA, Soto DA, Barrientos MJ, Carrión F, Kalergis AM, Vasquez AE. Molecular Immunology. DOI: 10.1016/j.molimm.2019.04.025. Related research line: Vaccine development against the respiratory syncytial virus. Publication date: 09-05-19.

63. Detection of a novel severe mutation affecting the CYP21A2 gene in a Chilean male with salt wasting congenital adrenal hyperplasia. Arteaga E, Valenzuela F, Lagos CF, Lagos M, Martinez A, Baudrand R, Carvajal C, Fardella CE. Endocrine. DOI: 10.1007/s12020-019-02097-3. Related research line: Endocrine Hypertension. Publication date: 30-09-19.

64. [Update in the clinical management of low renin hypertension]. Macchiavello S, Fardella C, Baudrand R. Revista Medica de Chile. DOI: 10.4067/S0034-98872019000400490. Related research line: Endocrine Hypertension. Publication date: 01-04-19.

65. Classic and nonclassic apparent mineralocorticoid excess. Cristian A. Carvajal, Alejandra Tapia-Castillo, Andrea Vecchiola, Rene Baudrand, Carlos E. Fardella Journal of Clinical Endocrinology & Metabolism. DOI: 10.1210/clinem/dgz315 Related research line: Endocrine Hypertension. Publication date: 01-12-19.

66. The absence of interleukin 10 affects the morphology, differentiation, granule content and the production of cryptidin-4 in Paneth cells in mice. Berkowitz L, Pardo-Roa C, Ramírez G, Vallejos OP, Sebastián VP, Riedel CA, Álvarez-Lobos M, Bueno SM PLoS One. DOI: 10.1371/journal.pone.0221618. Related research line: IBD implications in Paneth Cells in patients that are smokers. Publication date: 11-09-19.

67. Herpes Simplex Virus Type 1 Infection of the Central Nervous System: Insights Into Proposed Interrelationships With Neurodegenerative Disorders. Duarte LF, Farías MA, Álvarez DM, Bueno SM, Riedel CA, González PA. Frontiers in Cellular Neuroscience. DOI: 10.3389/fncel.2019.00046. Related research line: Effect of herpes simplex virus infection over host susceptibility to neurological inflammatory diseases. Publication date: 26-02-19.

68. Pathogenicity island excision during an infection by Salmonella enterica serovar Enteritidis is required for crossing the intestinal epithelial barrier in mice to cause systemic infection. Pardo-Roa C, Salazar GA, Noguera L, Salazar-Echegarai FJ, Vallejos OP, Suazo I, Schultz BM, Coronado-Arrazola I, Kalergis AM, Bueno SM. PLoS Pathogens. DOI: 10.1371/journal.ppat.1008152. Related research line: Lateral transfer of genes in Salmonella and its role in virulence. Publication date: 04-12-19.

69. Contribution of Cytokines to Tissue Damage During Human Respiratory Syncytial Virus Infection. Bohmwald K, Gálvez NMS, Canedo-Marroquín G, Pizarro-Ortega MS, Andrade-Parra C, Gómez-Santander F, Kalergis AM. Frontiers in Immunology. DOI: 10.3389/fimmu.2019.00452.Related research line: Mechanisms of pathogenicity used by the human Respiratory Syncytial Virus to prevent T cell activation and cause Central Nervous System inflammation. Publication date: 18-03-19.

70. Herpes Simplex Virus Evasion of Early Host Antiviral Responses. Tognarelli EI, Palomino TF, Corrales N, Bueno SM, Kalergis AM, González PA. Frontiers in Cellular and Infection Microbiology. DOI: 10.3389/fcimb.2019.00127. Publication date: 30-04-19.

71. Contribution of IDO to human respiratory syncytial virus infection Benavente FM, Soto JA, Pizarro-Ortega MS, Bohmwald K, González PA, Bueno SM, Kalergis AM. Journal of Leukocyte Biology. DOI: 10.1002/JLB.4RU0219-051RR. Related research line: Mechanisms of pathogenicity used by the human Respiratory Syncytial Virus to prevent T cell activation and cause Central Nervous System inflammation. Publication date: 15-05-19.

72. Characterization of LDLR rs5925 and PCSK9 rs505151 genetic variants frequencies in healthy subjects from northern Chile: Influence on plasma lipid levels. Rojas C, Ramírez H, Salazar LA, Kalergis AM, Gálvez AS, Escobar-Vera J. Journal of Clinical Laboratory Analysis. DOI: 10.1002/jcla.23001. Related research line: Discovery and characterization of novel genetic etiologies of primary immunodeficiencies. Publication date: 22-08-19.

73. Lithraea caustic (Litre) Extract Promotes an Antitumor Response Against B16 Melanoma Robles-Planells C, Michelson SA, Mena J, Escrig D, Rojas JL, Sanchez-Guerrero G, Hernández R, Barrera-Avalos C, Rojo LE, Sauma D, Kalergis AM, Imarai M, Fernández R, Robles CA, Leiva-Salcedo E, Santander R, Escobar A, Acuña-Castillo C. Frontiers in Pharmacology. DOI: 10.3389/fphar.2019.01201. Related research line: Immunology and Cancer. Publication date: 22-10-19.

74. Rho-kinase pathway activation and apoptosis in circulating leucocytes in patients with heart failure with reduced ejection fraction. Ocaranza MP, Moya J, Jalil JE, Lavandero S, Kalergis AM, Molina C, Gabrielli L, Godoy I, Córdova S, Castro P, Mac Nab P, Rossel V, García L, González J, Mancilla C, Fierro C, Farías L. Journal of Cellular and Molecular Medicine. DOI: 10.1111/jcmm.14819. Related research line: Discovery and characterization of novel genetic etiologies of primary immunodeficiencies. Publication date: 28-11-19.

75. Contribution of Resident Memory CD8+ T Cells to Protective Immunity Against Respiratory Syncytial Virus and Their Impact on Vaccine Design. Retamal-Díaz A, Covián C, Pacheco GA, Castiglione-Matamala AT, Bueno SM, González PA, Kalergis AM. Pathogens. DOI: 10.3390/pathogens8030147. Related research line: Vaccine development against the respiratory syncytial virus. Publication date: 11-09-19.

76. Immune-Modulation by the Human Respiratory Syncytial Virus: Focus on Dendritic Cells. Eduardo I. Tognarelli, Susan M. Bueno and Pablo A. González Frontiers in Immunology. DOI: 10.3389/fimmu.2019.00810. Related research line: Vaccine development against the respiratory syncytial virus. Publication date: 15-04-19.

77. Current Animal Models for Understanding the Pathology Caused by the Respiratory Syncytial Virus. Altamirano-Lagos MJ, Díaz FE, Mansilla MA, Rivera-Pérez D, Soto D, McGill JL, Vasquez AE, Kalergis AM. Frontiers in Microbiology. DOI: 10.3389/fmicb.2019.00873. Related research line: Vaccine development against the respiratory syncytial virus. Publication date: 03-05-19.

78. The Neutrophil to Lymphocyte Ratio Predicts the Response to Neoadjuvant Chemotherapy in Luminal B Breast Cancer. Rivas M, Acevedo F, Dominguez F, Galindo H, Camus M, Oddo D, Villarroel A, Razmilic D, Peña J, Munoz Medel M, Navarro ME, Perez-Sepulveda A, Medina L, Merino T, Briones J, Kalergis A, Sanchez C. Asian Pacific Journal of Cancer Prevention. DOI: 10.31557/APJCP.2019.20.7.2209. Related research line: Immunology and Cancer. Publication date: 01-07-19.

79. Tolerogenic dendritic cell transfer ameliorates systemic lupus erythematosus in mice. Funes SC, Ríos M, Gómez-Santander F, Fernández-Fierro A, Altamirano-Lagos MJ, Rivera-Perez D, Pulgar-Sepúlveda R, Jara EL, Rebolledo-Zelada D, Villarroel A, Roa JC, Mackern-Oberti JP, Kalergis AM. Immunology. DOI: 10.1111/imm.13119. Related research line: Publication date: 07-10-19.

80. The OXPHOS supercomplex assembly factor HIG2A responds to changes in energetic metabolism and cell cycle. Salazar C, Elorza AA, Cofre G, Ruiz-Hincapie P, Shirihai O, Ruiz LM. J Cell Physiology. DOI: 10.1002/jcp.28362. Related research line: Bioenergetics in Cell Metabolism. Publication date: 30-03-19.

81. The Emerging Roles of Nicotinamide Adenine Dinucleotide Phosphate Oxidase 2 in Skeletal Muscle Redox Signaling and Metabolism. Henríquez-Olguín C1,2, Boronat S3, Cabello-Verrugio C4,5,6, Jaimovich E2, Hidalgo E3, Jensen TE1. Antioxid Redox Signal. DOI: 10.1089/ars.2018.7678. Related research line: Skeletal muscle wasting development in patients with chronic hepatic disease. Publication date: 20-12-19.

82. N-Acetyl Cysteine attenuates the sarcopenia and muscle apoptosis induces by Chronic liver disease. Ábrigo, J., Marín, T., Aguirre, F., Tacchi, F., Vilos, C., Simon, F., Arrese, M., Cabrera, D., Cabello-Verrugio, C Curr Mol Med. DOI: 10.2174/1566524019666190917124636. Related research line: Skeletal muscle wasting development in patients with chronic hepatic disease. Publication date: 30-12-19.

83. The p75NTR neurotrophin receptor is required to organize the mature neuromuscular synapse by regulating synaptic vesicle availability. Pérez, V., Bermedo-Garcia, F., Zelada, D., Court, F.A., Pérez. M.Á., Fuenzalida, M., Ábrigo, J., Cabello-Verrugio, C., Moya-Alvarado, G., Tapia, J.C., Valenzuela, V., Hetz, C., Bronfman, F.C., Henríquez, J.P. Acta Neuropathologica Communications. DOI: 10.1186/s40478-019-0802-7. Related research line: Skeletal muscle wasting development in patients with chronic hepatic disease. Publication date: 12-09-19.

84. Mitochondrial Dysfunction in Skeletal Muscle Pathologies. Abrigo J, Simon F, Cabrera D, Vilos C, Cabello-Verrugio C. Current Protein & Peptide Science. DOI: 10.2174/1389203720666190402100902. Related research line: Skeletal muscle wasting development in patients with chronic hepatic disease. Publication date: 30-12-19.

85. Rotavirus vaccines for infants. David O Matson, Miguel Luis O´Ryan Gallardo. UpToDate. 2019.

86. Norovirus. Miguel G O’Ryan, Neil R Blacklow. UpToDate. 2019.

87. Acute viral gastroenteritis in children in resource-rich countries: Clinical features and diagnosis. David O Matson, Miguel G O’Ryan. UpToDate. 2019.

88. Patient Education: Acute diarrhea in children (Beyond the Basics). Gary R Fleisher, David O Matson, Miguel G O’Ryan. UpToDate. 2019.

89. Acute viral gastroenteritis in children in resource-rich countries: management and Prevention. David O Matson, Miguel G O’Ryan. UpToDate. 2019.

90. Clinical manifestations and diagnosis of rotavirus infection. David O Matson, Miguel G O’Ryan. UpToDate. 2019.