Research Lines – Dr. Vicente Torres Gómez
Dr. Vicente Torres Gómez
Principal Investigator, Universidad de Chile.
He leads 2 research lines, both in the context of cell migration:
1. Role of endosomal traffic in tumor cell migration and metastasis.
2. Cell migration in wound healing.
His research is funded by sources from government agencies, including FONDECYT, FONDEF, FONDAP and Millennium Science Initiative. He has published more than 60 papers in renowned journals, half of them as corresponding author. He has served as editor and reviewer of different journals and belonged to the Study Group of Biology in FONDECYT. He has also filed patent applications based on his studies on salivary histatins.
Publications:
1. Torres, P., Hernández, N., Mateluna, C., Silva, P., Reyes, M., Solano, L., Venegas, S., Criollo, A., Nazmi, K., Bikker, FJ., Bolscher, JG., Garrido, M., Cáceres, M. & Torres VA. “Histatin-1 is a novel osteogenic factor that promotes bone cell adhesion, migration, and differentiation”. J Tissue Eng Regen Med 2021; 15(4): 336-346.
2. Fernández C., Burgos, A., Morales, D., Rosales-Rojas, R., Canelo, J., Vergara-Jaque, A., Vieira, G., da Silva, R., Sales, KU., Conboy, MJ., Bae, EJ., Park, KS., Torres, VA., Garrido, M., Cerda, O., Conboy, IM. & Cáceres, M. “TMPRSS11a is a novel age-altered, tissue specific regulator of migration and wound healing”. FASEB J 2021; 35(5): e21597.
3. Villanueva, AA., Sánchez-Gómez, P., Muñoz-Palma, E., Puvogel, S., Casas, BS., Arriagada, C., Peña-Villalobos, I., Lois, P., Ramírez, M., Lubieniecki, F., Casco, F., Gallegos, I., García-Castro, J., Torres, VA.* Palma, V.* “The Netrin-1-Neogenin-1 signaling axis controls neuroblastoma cell migration via integrin-β1 and focal adhesion kinase activation”. Cell Adh Migr 2021; 15(1): 58-73. *Co-correspondence.
4. Goñi, F., Peña-Oyarzún, D., Torres, VA. & Reyes, M. “Expression profile of components of the β-catenin destruction complex in oral dysplasia and oral cancer. Med Oral Patol Oral Cir Bucal 2021; Sep 25: 24528.
5. Reyes, M., Peña-Oyarzún, D., Silva, P., Venegas, S., Criollo, A. & Torres, V.A. “Nuclear accumulation of β-catenin is associated with endosomal sequestration of the destruction complex and increased activation of Rab5 in oral dysplasia”. FASEB J 2020; 34(3): 4009-4025.
6. Rivas, S., Silva, P., Reyes, M., Sepúlveda, H., Solano, L., Acuña, J., Guerrero, M., Varas-Godoy, M., Quest, AF., Montecino, M. & Torres, V.A. “The RabGEF ALS2 is a hypoxia inducible target associated with the acquisition of aggressive traits in tumor cells”. Sci Rep 2020; 10(1): 22302.
7. Reyes, M., Flores, T., Betancur, D., Peña-Oyarzún, D. & Torres, V.A. “Wnt/β-Catenin Signaling in Oral Carcinogenesis”. Int J Mol Sci 2020; 21(13): 4682.
8. Peña-Oyarzún, D., Reyes, M., Hernández, M., Kretschmar, C., Morselli, E., Ramirez, C., Lavandero, S., Torres, V.A. & Criollo A. “Role of Autophagy in the Microenvironment of Oral Squamous Cell Carcinoma”. Front Oncol 2020; 10: 602661.
9. Peña-Oyarzun, D., Rodriguez-Peña, M., Burgos, F., Vergara, A., Kretschmar, C., Sotomayor, C., Ramirez, C., De Smedt, H., Reyes, M., Perez, W., Torres, V.A., Morselli, E., Altamirano, F., Wilson, C., Hill, J., Lavandero, S. & Criollo, A. “PKD2/polycystin-2 induces autophagy by forming a complex with BECN1”. Autophagy 2020; Jun 30: 1-15.
10. Fernández, A., Veloso, P., Astorga, J., Rodríguez, C., Torres, V.A., Valdés, M., Garrido, M., Gebicke-Haerter, P. & Hernández, M. “Epigenetic regulation of TLR2-mediated periapical inflammation”. Int J Endod J 2020; 53(9): 1229-1237.
11. Díaz-Valdivia, N., Díaz, J., Contreras, P., Campos, A., Rojas, V., Burgos, R., Lobos, L., Torres, V.A., Perez, V., Frei, B., Leyton, L. & Quest, A.F. “The non-receptor tyrosine phosphatase type 14 blocks caveolin-1-enhanced cancer cell metastasis”. Oncogene 2020; 39(18): 3693-3709.
12. Reyes, M., Peña-Oyarzún, D., Maturana, A. & Torres, V.A. “Nuclear localization of β-catenin and expression of target genes are associated with increased Wnt secretion in oral dysplasia”. Oral Oncol 2019; 94: 58-67.
13. Arriagada, C., Silva, P., Millet, M., Solano, L., Moraga, C. & Torres, V.A. “Focal adhesion kinase-dependent activation of the early endocytic protein Rab5 is associated with cell migration. J Biol Chem 2019; 294(34): 12836-12845.
14. Castro, M., Torres, P., Solano, L., Córdova, L. & Torres, V.A. “Histatin-1 counteracts the cytotoxic and antimigratory effects of zoledronic acid in endothelial and osteoblast-like cells”. J Periodontol 2019; 90(7): 766-774.
15. Arriagada, C., Silva, P. & Torres, V.A. “Role of glycosylation in hypoxia-driven cell migration and invasion”. Cell Adh Migr 2019; 13(1): 13-22.
16. Villanueva, A., Puvogel, S., Lois, P., Muñoz, E., Ramírez, M., Lubieniecki, F., Casco, F., Gallegos, I., García, J., Sanchez-Gomez, P., Torres V.A., Palma V. “The Netrin-4/Laminin γ1/Neogenin-1 complex mediates migration in SK-N-SH neuroblastoma cells”. Cell Adh Migr 2019; 13(1): 33-40.
17. Torres, P., Castro, M., Reyes, M., Torres, V.A. “Histatins, wound healing and cell migration”. Oral Dis 2018; 24(7): 1150-1160.
18. Mendoza, P., Silva, P., Díaz, J., Arriagada, C., Canales, J., Cerda, O. & Torres, V.A. “Calpain2 mediates Rab5 driven focal adhesion disassembly and cell migration”. Cell Adh Migr 2018; 12(3): 185-194.
19. Castillo, J., Silva, P., Martinez, S., Torres, V.A. & Quest, A. “Hypoxia-Induced Caveolin-1 Expression Promotes Migration and Invasion of Tumor Cells”. Curr Mol Med 2018; 18(4):199-206.
20. Torres, P., Díaz, J., Arce, M., Silva, P., Mendoza, P., Lois, P., Molina Berríos, A., Owen, G., Palma, V. & Torres, V.A. “The salivary peptide histatin-1 promotes endothelial cell adhesion, migration, and angiogenesis”. FASEB J 2017; 31(11): 4946-4958.
21. Erices, R., Cubillos, S., Aravena, R., Santoro, F., Marquez, M., Orellana, R., Ramírez, C., González, P., Fuenzalida, P., Bravo, M., Oliva, B., Kato, S., Ibañez, C., Brañes, J., Bravo, E., Alonso, C., García, K., Arab, C., Torres, V.A., Godoy, A., Pereira, J., Cuello, M & Owen, G.I. “Diabetic concentrations of Metformin inhibit platelet-mediated ovarian cancer cell progression». Oncotarget 2017; 8(13): 20865-20880.
22. Díaz-Valdivia, N., Calderón, C., Díaz, J., Lobos-González, L., Sepulveda, H., Ortíz, R., Martinez, S., Silva, V., Maldonado, H., Silva, P., Wehinger, S., Burzio, V., Torres, V.A., Montecino, M., Leyton, L., Quest, A. “Anti-neoplastic drugs increase caveolin-1-dependent migration, invasion and metastasis of cancer cells”. Oncotarget 2017; 8(67): 111943-111965.
23. Arros, A., Falcón, P., Espinoza, N., Milla, L., Hernandez-SanMiguel E., Torres, V.A., Sanchez-Gomez, P., Palma, V. “The Netrin-4/ Neogenin-1 axis promotes neuroblastoma cell survival and migration”. Oncotarget 2017; 8(6): 9767-9782.
24. Ortiz, R., Díaz, J., Díaz, N., Lobos-Gonzalez, L., Cárdenas, A., Contreras, P., Díaz, M., Otte, E., Cooper-White, J., Torres, V.A., Leyton, L. & Quest, A. “Extracellular matrix-specific Caveolin 1 phosphorylation on tyrosine 14 is linked to augmented melanoma metastasis but not tumorigenesis”. Oncotarget 2016; 7(26): 40571-40593.
25. Silva, P., Mendoza, P., Díaz, J., Rivas, S., Moraga, C., Quest, A. & Torres, V.A. «Hypoxia promotes Rab5 activation, leading to tumor cell migration, invasion and metastasis». Oncotarget 2016; 7(20):29548-29562.
F1000 Recommended (http://f1000.com/prime/726319359). F1000Prime, 14 Nov 2016; DOI: 10.3410/f.726319359.793525191. F1000Prime.com/726319359#eval793525191
26. Silva, P., Soto, N., Díaz, J., Mendoza, P., Díaz, N., Quest, A.F.G & Torres, V.A. “Down-regulation of Rab5 decreases characteristics associated with maintenance of cell transformation”. Biochem Biophys Res Commun 2015; 464(2): 642-646.
27. Díaz, J., Mendoza, P., Silva, P., Quest, A.F.G. & Torres, V.A. “A novel caveolin 1/p85α/Rab5/Tiam1/Rac1 signaling axis in tumor cell migration and invasion”. Commun Integr Biol 2014; 7(5): 1-3.
28. Díaz, J., Díaz, N., Leyton, L., Torres, V.A. & Quest, A.F.G. “Molecular mechanisms implicated in Caveolin 1 dependent Rab5 activation, migration and invasion of metastatic cancer cells”. Cancer Cell & Microenvironment 2014; 1(5): e332.
29. Díaz, J., Mendoza, P., Ortiz, R., Díaz, N., Leyton, L., Stupack, D., Quest, A.F.G. & Torres, V.A. “Rab5 is required for Caveolin-1-enhanced Rac1 activation, migration and invasion of metastatic cancer cells”. J Cell Sci 2014; 127(Pt 11): 2401-2406.
30. Torres, V.A. “Rab’ing tumor cell migration and invasion: focal adhesion disassembly driven by Rab5”. Cell Adh Migr 2014; 8(2): 84-87.
31. Mendoza, P., Díaz, J., Silva, P. & Torres, V.A. “Rab5 activation as a tumor cell migration switch”. Small GTPases 2014; 5(1): e28195-1.
32. Mendoza, P., Díaz, J. & Torres, V.A. “On the role of Rab5 in cell migration”. Curr Mol Med 2014; 14(2): 235-245.
33. Leyton, L., Torres, V.A. & Quest, A.F. “Editorial: Signaling in cell migration and disease”. Curr Mol Med 2014; 14(2): 197-8.
Patent Applications
Provisional Patent Application in the US (application #62944713)
“HISTATIN-1 FORMULATION FOR THE TREATMENT, REPAIR OR REGENERATION OF BONE TISSUE IN A SUBJECT”.
Inventors: Torres, P., Morales, J., Cáceres, M., Silva, P. & Torres, V.A.