Líneas de Investigación – Dr. Vicente Torres Gómez
Dr. Vicente Torres Gómez
Investigador Principal Universidad de Chile.
Vicente lidera 2 líneas de investigación, ambas en el contexto de la migración celular:
1. Papel del tráfico endosomal en la migración y metástasis de células tumorales.
2. Migración celular en la reparación de heridas.
Su investigación es financiada por instituciones gubernamentales, como FONDECYT, FONDEF, FONDAP e Iniciativa Científica Milenio. Ha publicado más de 60 artículos en revistas ISI de renombre, la mitad de ellos como autor correspondiente. Se ha desempeñado como editor y revisor de diferentes revistas y como evaluador del Grupo de Estudio de Biología en FONDECYT. También ha presentado solicitudes de patente basadas en sus estudios sobre las moléculas salivales histatinas.
Publicaciones:
1. Torres, P., Hernández, N., Mateluna, C., Silva, P., Reyes, M., Solano, L., Venegas, S., Criollo, A., Nazmi, K., Bikker, FJ., Bolscher, JG., Garrido, M., Cáceres, M. & Torres VA. “Histatin-1 is a novel osteogenic factor that promotes bone cell adhesion, migration, and differentiation”. J Tissue Eng Regen Med 2021; 15(4): 336-346.
2. Fernández C., Burgos, A., Morales, D., Rosales-Rojas, R., Canelo, J., Vergara-Jaque, A., Vieira, G., da Silva, R., Sales, KU., Conboy, MJ., Bae, EJ., Park, KS., Torres, VA., Garrido, M., Cerda, O., Conboy, IM. & Cáceres, M. “TMPRSS11a is a novel age-altered, tissue specific regulator of migration and wound healing”. FASEB J 2021; 35(5): e21597.
3. Villanueva, AA., Sánchez-Gómez, P., Muñoz-Palma, E., Puvogel, S., Casas, BS., Arriagada, C., Peña-Villalobos, I., Lois, P., Ramírez, M., Lubieniecki, F., Casco, F., Gallegos, I., García-Castro, J., Torres, VA.* Palma, V.* “The Netrin-1-Neogenin-1 signaling axis controls neuroblastoma cell migration via integrin-β1 and focal adhesion kinase activation”. Cell Adh Migr 2021; 15(1): 58-73. *Co-correspondence.
4. Goñi, F., Peña-Oyarzún, D., Torres, VA. & Reyes, M. “Expression profile of components of the β-catenin destruction complex in oral dysplasia and oral cancer. Med Oral Patol Oral Cir Bucal 2021; Sep 25: 24528.
5. Reyes, M., Peña-Oyarzún, D., Silva, P., Venegas, S., Criollo, A. & Torres, V.A. “Nuclear accumulation of β-catenin is associated with endosomal sequestration of the destruction complex and increased activation of Rab5 in oral dysplasia”. FASEB J 2020; 34(3): 4009-4025.
6. Rivas, S., Silva, P., Reyes, M., Sepúlveda, H., Solano, L., Acuña, J., Guerrero, M., Varas-Godoy, M., Quest, AF., Montecino, M. & Torres, V.A. “The RabGEF ALS2 is a hypoxia inducible target associated with the acquisition of aggressive traits in tumor cells”. Sci Rep 2020; 10(1): 22302.
7. Reyes, M., Flores, T., Betancur, D., Peña-Oyarzún, D. & Torres, V.A. “Wnt/β-Catenin Signaling in Oral Carcinogenesis”. Int J Mol Sci 2020; 21(13): 4682.
8. Peña-Oyarzún, D., Reyes, M., Hernández, M., Kretschmar, C., Morselli, E., Ramirez, C., Lavandero, S., Torres, V.A. & Criollo A. “Role of Autophagy in the Microenvironment of Oral Squamous Cell Carcinoma”. Front Oncol 2020; 10: 602661.
9. Peña-Oyarzun, D., Rodriguez-Peña, M., Burgos, F., Vergara, A., Kretschmar, C., Sotomayor, C., Ramirez, C., De Smedt, H., Reyes, M., Perez, W., Torres, V.A., Morselli, E., Altamirano, F., Wilson, C., Hill, J., Lavandero, S. & Criollo, A. “PKD2/polycystin-2 induces autophagy by forming a complex with BECN1”. Autophagy 2020; Jun 30: 1-15.
10. Fernández, A., Veloso, P., Astorga, J., Rodríguez, C., Torres, V.A., Valdés, M., Garrido, M., Gebicke-Haerter, P. & Hernández, M. “Epigenetic regulation of TLR2-mediated periapical inflammation”. Int J Endod J 2020; 53(9): 1229-1237.
11. Díaz-Valdivia, N., Díaz, J., Contreras, P., Campos, A., Rojas, V., Burgos, R., Lobos, L., Torres, V.A., Perez, V., Frei, B., Leyton, L. & Quest, A.F. “The non-receptor tyrosine phosphatase type 14 blocks caveolin-1-enhanced cancer cell metastasis”. Oncogene 2020; 39(18): 3693-3709.
12. Reyes, M., Peña-Oyarzún, D., Maturana, A. & Torres, V.A. “Nuclear localization of β-catenin and expression of target genes are associated with increased Wnt secretion in oral dysplasia”. Oral Oncol 2019; 94: 58-67.
13. Arriagada, C., Silva, P., Millet, M., Solano, L., Moraga, C. & Torres, V.A. “Focal adhesion kinase-dependent activation of the early endocytic protein Rab5 is associated with cell migration. J Biol Chem 2019; 294(34): 12836-12845.
14. Castro, M., Torres, P., Solano, L., Córdova, L. & Torres, V.A. “Histatin-1 counteracts the cytotoxic and antimigratory effects of zoledronic acid in endothelial and osteoblast-like cells”. J Periodontol 2019; 90(7): 766-774.
15. Arriagada, C., Silva, P. & Torres, V.A. “Role of glycosylation in hypoxia-driven cell migration and invasion”. Cell Adh Migr 2019; 13(1): 13-22.
16. Villanueva, A., Puvogel, S., Lois, P., Muñoz, E., Ramírez, M., Lubieniecki, F., Casco, F., Gallegos, I., García, J., Sanchez-Gomez, P., Torres V.A., Palma V. “The Netrin-4/Laminin γ1/Neogenin-1 complex mediates migration in SK-N-SH neuroblastoma cells”. Cell Adh Migr 2019; 13(1): 33-40.
17. Torres, P., Castro, M., Reyes, M., Torres, V.A. “Histatins, wound healing and cell migration”. Oral Dis 2018; 24(7): 1150-1160.
18. Mendoza, P., Silva, P., Díaz, J., Arriagada, C., Canales, J., Cerda, O. & Torres, V.A. “Calpain2 mediates Rab5 driven focal adhesion disassembly and cell migration”. Cell Adh Migr 2018; 12(3): 185-194.
19. Castillo, J., Silva, P., Martinez, S., Torres, V.A. & Quest, A. “Hypoxia-Induced Caveolin-1 Expression Promotes Migration and Invasion of Tumor Cells”. Curr Mol Med 2018; 18(4):199-206.
20. Torres, P., Díaz, J., Arce, M., Silva, P., Mendoza, P., Lois, P., Molina Berríos, A., Owen, G., Palma, V. & Torres, V.A. “The salivary peptide histatin-1 promotes endothelial cell adhesion, migration, and angiogenesis”. FASEB J 2017; 31(11): 4946-4958.
21. Erices, R., Cubillos, S., Aravena, R., Santoro, F., Marquez, M., Orellana, R., Ramírez, C., González, P., Fuenzalida, P., Bravo, M., Oliva, B., Kato, S., Ibañez, C., Brañes, J., Bravo, E., Alonso, C., García, K., Arab, C., Torres, V.A., Godoy, A., Pereira, J., Cuello, M & Owen, G.I. “Diabetic concentrations of Metformin inhibit platelet-mediated ovarian cancer cell progression». Oncotarget 2017; 8(13): 20865-20880.
22. Díaz-Valdivia, N., Calderón, C., Díaz, J., Lobos-González, L., Sepulveda, H., Ortíz, R., Martinez, S., Silva, V., Maldonado, H., Silva, P., Wehinger, S., Burzio, V., Torres, V.A., Montecino, M., Leyton, L., Quest, A. “Anti-neoplastic drugs increase caveolin-1-dependent migration, invasion and metastasis of cancer cells”. Oncotarget 2017; 8(67): 111943-111965.
23. Arros, A., Falcón, P., Espinoza, N., Milla, L., Hernandez-SanMiguel E., Torres, V.A., Sanchez-Gomez, P., Palma, V. “The Netrin-4/ Neogenin-1 axis promotes neuroblastoma cell survival and migration”. Oncotarget 2017; 8(6): 9767-9782.
24. Ortiz, R., Díaz, J., Díaz, N., Lobos-Gonzalez, L., Cárdenas, A., Contreras, P., Díaz, M., Otte, E., Cooper-White, J., Torres, V.A., Leyton, L. & Quest, A. “Extracellular matrix-specific Caveolin 1 phosphorylation on tyrosine 14 is linked to augmented melanoma metastasis but not tumorigenesis”. Oncotarget 2016; 7(26): 40571-40593.
25. Silva, P., Mendoza, P., Díaz, J., Rivas, S., Moraga, C., Quest, A. & Torres, V.A. «Hypoxia promotes Rab5 activation, leading to tumor cell migration, invasion and metastasis». Oncotarget 2016; 7(20):29548-29562.
F1000 Recommended (http://f1000.com/prime/726319359). F1000Prime, 14 Nov 2016; DOI: 10.3410/f.726319359.793525191. F1000Prime.com/726319359#eval793525191
26. Silva, P., Soto, N., Díaz, J., Mendoza, P., Díaz, N., Quest, A.F.G & Torres, V.A. “Down-regulation of Rab5 decreases characteristics associated with maintenance of cell transformation”. Biochem Biophys Res Commun 2015; 464(2): 642-646.
27. Díaz, J., Mendoza, P., Silva, P., Quest, A.F.G. & Torres, V.A. “A novel caveolin 1/p85α/Rab5/Tiam1/Rac1 signaling axis in tumor cell migration and invasion”. Commun Integr Biol 2014; 7(5): 1-3.
28. Díaz, J., Díaz, N., Leyton, L., Torres, V.A. & Quest, A.F.G. “Molecular mechanisms implicated in Caveolin 1 dependent Rab5 activation, migration and invasion of metastatic cancer cells”. Cancer Cell & Microenvironment 2014; 1(5): e332.
29. Díaz, J., Mendoza, P., Ortiz, R., Díaz, N., Leyton, L., Stupack, D., Quest, A.F.G. & Torres, V.A. “Rab5 is required for Caveolin-1-enhanced Rac1 activation, migration and invasion of metastatic cancer cells”. J Cell Sci 2014; 127(Pt 11): 2401-2406.
30. Torres, V.A. “Rab’ing tumor cell migration and invasion: focal adhesion disassembly driven by Rab5”. Cell Adh Migr 2014; 8(2): 84-87.
31. Mendoza, P., Díaz, J., Silva, P. & Torres, V.A. “Rab5 activation as a tumor cell migration switch”. Small GTPases 2014; 5(1): e28195-1.
32. Mendoza, P., Díaz, J. & Torres, V.A. “On the role of Rab5 in cell migration”. Curr Mol Med 2014; 14(2): 235-245.
33. Leyton, L., Torres, V.A. & Quest, A.F. “Editorial: Signaling in cell migration and disease”. Curr Mol Med 2014; 14(2): 197-8.
Patent Applications
Provisional Patent Application in the US (application #62944713)
“HISTATIN-1 FORMULATION FOR THE TREATMENT, REPAIR OR REGENERATION OF BONE TISSUE IN A SUBJECT”.
Inventors: Torres, P., Morales, J., Cáceres, M., Silva, P. & Torres, V.A.